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6,969 results

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Loss of H3K9 trimethylation leads to premature aging.
Mrabti C, Yang N, Desdín-Micó G, Alonso-Calleja A, Vílchez-Acosta A, Pico S, Parras A, Piao Y, Schoenfeldt L, Luo S, Haghani A, Brooke R, Del Carmen Maza M, Branchina C, Maroun CY, von Meyenn F, Naveiras O, Horvath S, Sen P, Ocampo A. Mrabti C, et al. Among authors: yang n. bioRxiv [Preprint]. 2024 Jul 24:2024.07.24.604929. doi: 10.1101/2024.07.24.604929. bioRxiv. 2024. PMID: 39091811 Free PMC article. Preprint.
The senescent cell epigenome.
Yang N, Sen P. Yang N, et al. Aging (Albany NY). 2018 Nov 3;10(11):3590-3609. doi: 10.18632/aging.101617. Aging (Albany NY). 2018. PMID: 30391936 Free PMC article. Review.
A gradual path to mortality.
Yang N, Sen P. Yang N, et al. Elife. 2022 Mar 18;11:e77749. doi: 10.7554/eLife.77749. Elife. 2022. PMID: 35302485 Free PMC article.
A hyper-quiescent chromatin state formed during aging is reversed by regeneration.
Yang N, Occean JR, Melters DP, Shi C, Wang L, Stransky S, Doyle ME, Cui CY, Delannoy M, Fan J, Slama E, Egan JM, De S, Cunningham SC, de Cabo R, Sidoli S, Dalal Y, Sen P. Yang N, et al. bioRxiv [Preprint]. 2023 Feb 15:2023.02.14.528512. doi: 10.1101/2023.02.14.528512. bioRxiv. 2023. Update in: Mol Cell. 2023 May 18;83(10):1659-1676.e11. doi: 10.1016/j.molcel.2023.04.005. PMID: 36824822 Free PMC article. Updated. Preprint.
Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging.
Occean JR, Yang N, Sun Y, Dawkins MS, Munk R, Belair C, Dar S, Anerillas C, Wang L, Shi C, Dunn C, Bernier M, Price NL, Kim JS, Cui CY, Fan J, Bhattacharyya M, De S, Maragkakis M, deCabo R, Sidoli S, Sen P. Occean JR, et al. Among authors: yang n. bioRxiv [Preprint]. 2024 Jul 3:2023.02.15.528714. doi: 10.1101/2023.02.15.528714. bioRxiv. 2024. Update in: Nat Commun. 2024 Jul 28;15(1):6357. doi: 10.1038/s41467-024-50725-y. PMID: 36824863 Free PMC article. Updated. Preprint.
A hyper-quiescent chromatin state formed during aging is reversed by regeneration.
Yang N, Occean JR, Melters DP, Shi C, Wang L, Stransky S, Doyle ME, Cui CY, Delannoy M, Fan J, Slama E, Egan JM, De S, Cunningham SC, de Cabo R, Sidoli S, Dalal Y, Sen P. Yang N, et al. Mol Cell. 2023 May 18;83(10):1659-1676.e11. doi: 10.1016/j.molcel.2023.04.005. Epub 2023 Apr 27. Mol Cell. 2023. PMID: 37116496 Free PMC article.
Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4.
Meng Q, Chen C, Yang N, Gololobova O, Shi C, Dunn CA, Rossi M, Martindale JL, Basisty N, Ding J, Delannoy M, Basu S, Mazan-Mamczarz K, Shin CH, Yang JH, Johnson PF, Witwer KW, Biragyn A, Sen P, Abdelmohsen K, De S, Gorospe M. Meng Q, et al. Among authors: yang jh, yang n. Proc Natl Acad Sci U S A. 2023 Oct 24;120(43):e2219801120. doi: 10.1073/pnas.2219801120. Epub 2023 Oct 20. Proc Natl Acad Sci U S A. 2023. PMID: 37862381 Free PMC article.
6,969 results