Varney MA - Search Results

1

Pharmacodynamic, pharmacokinetic and rat brain receptor occupancy profile of NLX-112, a highly selective 5-HT_1A receptor biased agonist.

Depoortère RY, McCreary AC, Vidal B, Varney MA, Zimmer L, Newman-Tancredi A. Depoortère RY, et al. Among authors: varney ma. Naunyn Schmiedebergs Arch Pharmacol. 2024 Aug 3. doi: 10.1007/s00210-024-03323-0. Online ahead of print. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 39096379

2

Acute and Repeated Administration of NLX-101, a Selective Serotonin-1A Receptor Biased Agonist, Reduces Audiogenic Seizures in Developing Fmr1 Knockout Mice.

Tao X, Newman-Tancredi A, Varney MA, Razak KA. Tao X, et al. Among authors: varney ma. Neuroscience. 2023 Jan 15;509:113-124. doi: 10.1016/j.neuroscience.2022.11.014. Epub 2022 Nov 21. Neuroscience. 2023. PMID: 36410632

3

NLX-101, a 5-HT_1A receptor-biased agonist, improves pattern separation and stimulates neuroplasticity in aged rats.

Aguiar RP, Soares LM, Varney M, Newman-Tancredi A A, Milani H, Prickaerts J, de Oliveira RMW. Aguiar RP, et al. Neurobiol Aging. 2023 Apr;124:52-59. doi: 10.1016/j.neurobiolaging.2022.12.013. Epub 2022 Dec 31. Neurobiol Aging. 2023. PMID: 36739621

4

The selective 5-HT 1A receptor agonist, NLX-112, overcomes tetrabenazine-induced catalepsy and depression-like behavior in the rat.

Jastrzębska-Więsek M, Wesołowska A, Kołaczkowski M, Varney MA, Newman-Tancredi A, Depoortere R. Jastrzębska-Więsek M, et al. Among authors: varney ma. Behav Pharmacol. 2022 Aug 1;33(5):333-341. doi: 10.1097/FBP.0000000000000681. Epub 2022 Jun 9. Behav Pharmacol. 2022. PMID: 35695543

5

NLX-112, a highly selective 5-HT_1A receptor biased agonist, does not exhibit misuse potential in male rats or macaques.

Depoortère R, Bergman J, Beardsley PM, Desai RI, Paronis CA, Walentiny DM, Varney MA, Newman-Tancredi A. Depoortère R, et al. Among authors: varney ma. Neuropharmacology. 2022 Jun 1;210:109025. doi: 10.1016/j.neuropharm.2022.109025. Epub 2022 Mar 9. Neuropharmacology. 2022. PMID: 35276118 Free PMC article.

6

Dissecting the contribution of 5-HT_1A auto- and heteroreceptors in sucrose overconsumption in mice.

Beecher K, Wang J, Chehrehasa F, Depoortere R, Varney MA, Newman-Tancredi A, Bartlett SE, Belmer A. Beecher K, et al. Among authors: varney ma. Biomed Pharmacother. 2022 Apr;148:112699. doi: 10.1016/j.biopha.2022.112699. Epub 2022 Feb 11. Biomed Pharmacother. 2022. PMID: 35152045 Free article.

7

Identification of the 5-HT_1A serotonin receptor as a novel therapeutic target in a C. elegans model of Machado-Joseph disease.

Pereira-Sousa J, Ferreira-Lomba B, Bellver-Sanchis A, Vilasboas-Campos D, Fernandes JH, Costa MD, Varney MA, Newman-Tancredi A, Maciel P, Teixeira-Castro A. Pereira-Sousa J, et al. Among authors: varney ma. Neurobiol Dis. 2021 May;152:105278. doi: 10.1016/j.nbd.2021.105278. Epub 2021 Jan 28. Neurobiol Dis. 2021. PMID: 33516872 Free article.

8

The selective 5-HT_1A receptor agonist, NLX-112, exerts anti-dyskinetic and anti-parkinsonian-like effects in MPTP-treated marmosets.

Fisher R, Hikima A, Morris R, Jackson MJ, Rose S, Varney MA, Depoortere R, Newman-Tancredi A. Fisher R, et al. Among authors: varney ma. Neuropharmacology. 2020 May 1;167:107997. doi: 10.1016/j.neuropharm.2020.107997. Epub 2020 Feb 10. Neuropharmacology. 2020. PMID: 32057799 Free PMC article.

9

Bell-shaped agonist activation of 5-HT_1A receptor-coupled Gαi₃ G-proteins: Receptor density-dependent switch in receptor signaling.

Newman-Tancredi A, Cussac D, Ormière AM, Lestienne F, Varney MA, Martel JC. Newman-Tancredi A, et al. Among authors: varney ma. Cell Signal. 2019 Nov;63:109383. doi: 10.1016/j.cellsig.2019.109383. Epub 2019 Jul 31. Cell Signal. 2019. PMID: 31376526

10

Cortical 5-hydroxytryptamine 1A receptor biased agonist, NLX-101, displays rapid-acting antidepressant-like properties in the rat chronic mild stress model.

Depoortère R, Papp M, Gruca P, Lason-Tyburkiewicz M, Niemczyk M, Varney MA, Newman-Tancredi A. Depoortère R, et al. Among authors: varney ma. J Psychopharmacol. 2019 Nov;33(11):1456-1466. doi: 10.1177/0269881119860666. Epub 2019 Jul 10. J Psychopharmacol. 2019. PMID: 31290370

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