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Page 1
Systematic multi-trait AAV capsid engineering for efficient gene delivery.
Eid FE, Chen AT, Chan KY, Huang Q, Zheng Q, Tobey IG, Pacouret S, Brauer PP, Keyes C, Powell M, Johnston J, Zhao B, Lage K, Tarantal AF, Chan YA, Deverman BE. Eid FE, et al. Among authors: tobey ig. Nat Commun. 2024 Aug 4;15(1):6602. doi: 10.1038/s41467-024-50555-y. Nat Commun. 2024. PMID: 39097583 Free PMC article.
An AAV capsid reprogrammed to bind human transferrin receptor mediates brain-wide gene delivery.
Huang Q, Chan KY, Wu J, Botticello-Romero NR, Zheng Q, Lou S, Keyes C, Svanbergsson A, Johnston J, Mills A, Lin CY, Brauer PP, Clouse G, Pacouret S, Harvey JW, Beddow T, Hurley JK, Tobey IG, Powell M, Chen AT, Barry AJ, Eid FE, Chan YA, Deverman BE. Huang Q, et al. Among authors: tobey ig. Science. 2024 Jun 14;384(6701):1220-1227. doi: 10.1126/science.adm8386. Epub 2024 May 16. Science. 2024. PMID: 38753766
An AAV capsid reprogrammed to bind human Transferrin Receptor mediates brain-wide gene delivery.
Huang Q, Chan KY, Lou S, Keyes C, Wu J, Botticello-Romero NR, Zheng Q, Johnston J, Mills A, Brauer PP, Clouse G, Pacouret S, Harvey JW, Beddow T, Hurley JK, Tobey IG, Powell M, Chen AT, Barry AJ, Eid FE, Chan YA, Deverman BE. Huang Q, et al. Among authors: tobey ig. bioRxiv [Preprint]. 2023 Dec 22:2023.12.20.572615. doi: 10.1101/2023.12.20.572615. bioRxiv. 2023. Update in: Science. 2024 Jun 14;384(6701):1220-1227. doi: 10.1126/science.adm8386. PMID: 38187643 Free PMC article. Updated. Preprint.
Targeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier.
Huang Q, Chen AT, Chan KY, Sorensen H, Barry AJ, Azari B, Zheng Q, Beddow T, Zhao B, Tobey IG, Moncada-Reid C, Eid FE, Walkey CJ, Ljungberg MC, Lagor WR, Heaney JD, Chan YA, Deverman BE. Huang Q, et al. Among authors: tobey ig. PLoS Biol. 2023 Jul 19;21(7):e3002112. doi: 10.1371/journal.pbio.3002112. eCollection 2023 Jul. PLoS Biol. 2023. PMID: 37467291 Free PMC article.
Synonymous nucleotide changes drive papillomavirus evolution.
King KM, Rajadhyaksha EV, Tobey IG, Van Doorslaer K. King KM, et al. Among authors: tobey ig. Tumour Virus Res. 2022 Dec;14:200248. doi: 10.1016/j.tvr.2022.200248. Epub 2022 Oct 17. Tumour Virus Res. 2022. PMID: 36265836 Free PMC article. Review.