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An improved SNAP-ADAR tool enables efficient RNA base editing to interfere with post-translational protein modification.
Kiran Kumar KD, Singh S, Schmelzle SM, Vogel P, Fruhner C, Hanswillemenke A, Brun A, Wettengel J, Füll Y, Funk L, Mast V, Botsch JJ, Reautschnig P, Li JB, Stafforst T. Kiran Kumar KD, et al. Among authors: reautschnig p. Nat Commun. 2024 Aug 5;15(1):6615. doi: 10.1038/s41467-024-50395-w. Nat Commun. 2024. PMID: 39103360 Free PMC article.
Precise in vivo RNA base editing with a wobble-enhanced circular CLUSTER guide RNA.
Reautschnig P, Fruhner C, Wahn N, Wiegand CP, Kragness S, Yung JF, Hofacker DT, Fisk J, Eidelman M, Waffenschmidt N, Feige M, Pfeiffer LS, Schulz AE, Füll Y, Levanon EY, Mandel G, Stafforst T. Reautschnig P, et al. Nat Biotechnol. 2024 Jul 12. doi: 10.1038/s41587-024-02313-0. Online ahead of print. Nat Biotechnol. 2024. PMID: 38997581
In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency.
Mahiny AJ, Dewerth A, Mays LE, Alkhaled M, Mothes B, Malaeksefat E, Loretz B, Rottenberger J, Brosch DM, Reautschnig P, Surapolchai P, Zeyer F, Schams A, Carevic M, Bakele M, Griese M, Schwab M, Nürnberg B, Beer-Hammer S, Handgretinger R, Hartl D, Lehr CM, Kormann MS. Mahiny AJ, et al. Among authors: reautschnig p. Nat Biotechnol. 2015 Jun;33(6):584-6. doi: 10.1038/nbt.3241. Epub 2015 May 18. Nat Biotechnol. 2015. PMID: 25985262 No abstract available.