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Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance.
Thatikonda V, Lyu H, Jurado S, Kostyrko K, Bristow CA, Albrecht C, Alpar D, Arnhof H, Bergner O, Bosch K, Feng N, Gao S, Gerlach D, Gmachl M, Hinkel M, Lieb S, Jeschko A, Machado AA, Madensky T, Marszalek ED, Mahendra M, Melo-Zainzinger G, Molkentine JM, Jaeger PA, Peng DH, Schenk RL, Sorokin A, Strauss S, Trapani F, Kopetz S, Vellano CP, Petronczki M, Kraut N, Heffernan TP, Marszalek JR, Pearson M, Waizenegger IC, Hofmann MH. Thatikonda V, et al. Among authors: trapani f. Nat Cancer. 2024 Sep;5(9):1352-1370. doi: 10.1038/s43018-024-00800-6. Epub 2024 Aug 5. Nat Cancer. 2024. PMID: 39103541 Free PMC article.
Combined KRASG12C and SOS1 inhibition enhances and extends the anti-tumor response in KRASG12C-driven cancers by addressing intrinsic and acquired resistance.
Thatikonda V, Lu H, Jurado S, Kostyrko K, Bristow CA, Bosch K, Feng N, Gao S, Gerlach D, Gmachl M, Lieb S, Jeschko A, Machado AA, Marszalek ED, Mahendra M, Jaeger PA, Sorokin A, Strauss S, Trapani F, Kopetz S, Vellano CP, Petronczki M, Kraut N, Heffernan TP, Marszalek JR, Pearson M, Waizenegger I, Hofmann MH. Thatikonda V, et al. Among authors: trapani f. bioRxiv [Preprint]. 2023 Jan 23:2023.01.23.525210. doi: 10.1101/2023.01.23.525210. bioRxiv. 2023. Update in: Nat Cancer. 2024 Sep;5(9):1352-1370. doi: 10.1038/s43018-024-00800-6 PMID: 36747713 Free PMC article. Updated. Preprint.
Reshaping the Tumor Microenvironment of KRASG12D Pancreatic Ductal Adenocarcinoma with Combined SOS1 and MEK Inhibition for Improved Immunotherapy Response.
Norgard RJ, Budhani P, O'Brien SA, Xia Y, Egan JN, Flynn B, Tagore JR, Seco J, Peet GW, Mikucka A, Wasti R, Chan LC, Hinkel M, Martinez-Morilla S, Pignatelli J, Trapani F, Corse E, Feng D, Kostyrko K, Hofmann MH, Liu K, Kashyap AS. Norgard RJ, et al. Among authors: trapani f. Cancer Res Commun. 2024 Jun 21;4(6):1548-1560. doi: 10.1158/2767-9764.CRC-24-0172. Cancer Res Commun. 2024. PMID: 38727236 Free PMC article.
Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors.
Tarr JC, Salovich JM, Aichinger M, Jeon K, Veerasamy N, Sensintaffar JL, Arnhof H, Samwer M, Christov PP, Kim K, Wunberg T, Schweifer N, Trapani F, Arnold A, Martin F, Zhao B, Miriyala N, Sgubin D, Fogarty S, Moore WJ, Stott GM, Olejniczak ET, Engelhardt H, Rudolph D, Lee T, McConnell DB, Fesik SW. Tarr JC, et al. Among authors: trapani f. J Med Chem. 2024 Aug 22;67(16):14370-14393. doi: 10.1021/acs.jmedchem.4c01188. Epub 2024 Aug 5. J Med Chem. 2024. PMID: 39102508 Free PMC article.
Heterogeneous Profile of ROR1 Protein Expression across Tumor Types.
Raso MG, Barrientos Toro E, Evans K, Rizvi Y, Lazcano R, Akcakanat A, Sini P, Trapani F, Madlener EJ, Waldmeier L, Lazar A, Meric-Bernstam F. Raso MG, et al. Among authors: trapani f. Cancers (Basel). 2024 May 15;16(10):1874. doi: 10.3390/cancers16101874. Cancers (Basel). 2024. PMID: 38791952 Free PMC article.
Altered Functional Responses of the Retina in B6 Albino Tyrc/c Mice.
Chotard V, Trapani F, Glaziou G, Sermet BS, Yger P, Marre O, Rebsam A. Chotard V, et al. Among authors: trapani f. Invest Ophthalmol Vis Sci. 2024 Aug 1;65(10):39. doi: 10.1167/iovs.65.10.39. Invest Ophthalmol Vis Sci. 2024. PMID: 39189994 Free PMC article.
Evaluation of an impedance-based method to monitor the insertion of the electrode array during cochlear implantation.
Gottfried TM, Galeazzi P, Föger A, Dejaco D, Tröger A, Fischer N, Innerhofer V, Di Trapani F, Weiss N, Seebacher J, Dierker A, Schmutzhard J. Gottfried TM, et al. Among authors: di trapani f. Eur Arch Otorhinolaryngol. 2024 Aug;281(8):4121-4131. doi: 10.1007/s00405-024-08584-2. Epub 2024 Apr 2. Eur Arch Otorhinolaryngol. 2024. PMID: 38564010 Free PMC article.
Enhancing breast cancer screening with urinary biomarkers and Random Forest supervised classification: A comprehensive investigation.
Alladio E, Trapani F, Castellino L, Massano M, Di Corcia D, Salomone A, Berrino E, Ponzone R, Marchiò C, Sapino A, Vincenti M. Alladio E, et al. Among authors: trapani f. J Pharm Biomed Anal. 2024 Jul 15;244:116113. doi: 10.1016/j.jpba.2024.116113. Epub 2024 Mar 20. J Pharm Biomed Anal. 2024. PMID: 38554554 Free article.
103 results