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Combination Immune Checkpoint Blockade Enhances IL-2 and CD107a Production from HIV-Specific T Cells Ex Vivo in People Living with HIV on Antiretroviral Therapy.
Chiu CY, Chang JJ, Dantanarayana AI, Solomon A, Evans VA, Pascoe R, Gubser C, Trautman L, Fromentin R, Chomont N, McMahon JH, Cameron PU, Rasmussen TA, Lewin SR. Chiu CY, et al. J Immunol. 2022 Jan 1;208(1):54-62. doi: 10.4049/jimmunol.2100367. Epub 2021 Dec 1. J Immunol. 2022. PMID: 34853078 Free PMC article.
Memory CD4+ T cells that co-express PD1 and CTLA4 have reduced response to activating stimuli facilitating HIV latency.
Rasmussen TA, Zerbato JM, Rhodes A, Tumpach C, Dantanarayana A, McMahon JH, Lau JSY, Chang JJ, Gubser C, Brown W, Hoh R, Krone M, Pascoe R, Chiu CY, Bramhall M, Lee HJ, Haque A, Fromentin R, Chomont N, Milush J, Van der Sluis RM, Palmer S, Deeks SG, Cameron PU, Evans V, Lewin SR. Rasmussen TA, et al. Cell Rep Med. 2022 Oct 18;3(10):100766. doi: 10.1016/j.xcrm.2022.100766. Epub 2022 Oct 4. Cell Rep Med. 2022. PMID: 36198308 Free PMC article.
Multiply spliced HIV RNA is a predictive measure of virus production ex vivo and in vivo following reversal of HIV latency.
Zerbato JM, Khoury G, Zhao W, Gartner MJ, Pascoe RD, Rhodes A, Dantanarayana A, Gooey M, Anderson J, Bacchetti P, Deeks SG, McMahon J, Roche M, Rasmussen TA, Purcell DF, Lewin SR. Zerbato JM, et al. Among authors: pascoe rd. EBioMedicine. 2021 Mar;65:103241. doi: 10.1016/j.ebiom.2021.103241. Epub 2021 Feb 26. EBioMedicine. 2021. PMID: 33647768 Free PMC article.
Combination Immune Checkpoint Blockade to Reverse HIV Latency.
Van der Sluis RM, Kumar NA, Pascoe RD, Zerbato JM, Evans VA, Dantanarayana AI, Anderson JL, Sékaly RP, Fromentin R, Chomont N, Cameron PU, Lewin SR. Van der Sluis RM, et al. Among authors: pascoe rd. J Immunol. 2020 Mar 1;204(5):1242-1254. doi: 10.4049/jimmunol.1901191. Epub 2020 Jan 27. J Immunol. 2020. PMID: 31988180 Free PMC article.
Diverse effects of interferon alpha on the establishment and reversal of HIV latency.
Van der Sluis RM, Zerbato JM, Rhodes JW, Pascoe RD, Solomon A, Kumar NA, Dantanarayana AI, Tennakoon S, Dufloo J, McMahon J, Chang JJ, Evans VA, Hertzog PJ, Jakobsen MR, Harman AN, Lewin SR, Cameron PU. Van der Sluis RM, et al. Among authors: pascoe rd. PLoS Pathog. 2020 Feb 28;16(2):e1008151. doi: 10.1371/journal.ppat.1008151. eCollection 2020 Feb. PLoS Pathog. 2020. PMID: 32109259 Free PMC article.
Multiparameter immunohistochemistry analysis of HIV DNA, RNA and immune checkpoints in lymph node tissue.
Richardson ZA, Deleage C, Tutuka CSA, Walkiewicz M, Del Río-Estrada PM, Pascoe RD, Evans VA, Reyesteran G, Gonzales M, Roberts-Thomson S, González-Navarro M, Torres-Ruiz F, Estes JD, Lewin SR, Cameron PU. Richardson ZA, et al. Among authors: pascoe rd. J Immunol Methods. 2022 Feb;501:113198. doi: 10.1016/j.jim.2021.113198. Epub 2021 Dec 2. J Immunol Methods. 2022. PMID: 34863818 Free PMC article.
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