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Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.
Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR. Huang F, et al. Among authors: sheppard d. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16354-9. doi: 10.1073/pnas.1214596109. Epub 2012 Sep 17. Proc Natl Acad Sci U S A. 2012. PMID: 22988107 Free PMC article.
Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing.
Chen C, Kudo M, Rutaganira F, Takano H, Lee C, Atakilit A, Robinett KS, Uede T, Wolters PJ, Shokat KM, Huang X, Sheppard D. Chen C, et al. Among authors: sheppard d. J Clin Invest. 2012 Aug;122(8):2916-27. doi: 10.1172/JCI60387. Epub 2012 Jul 9. J Clin Invest. 2012. PMID: 22772469 Free PMC article.
Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness.
Sundaram A, Chen C, Isik Reed N, Liu S, Ki Yeon S, McIntosh J, Tang YZ, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H. Sundaram A, et al. Among authors: sheppard d. Bioorg Med Chem Lett. 2020 Nov 15;30(22):127578. doi: 10.1016/j.bmcl.2020.127578. Epub 2020 Sep 29. Bioorg Med Chem Lett. 2020. PMID: 33007395 Free PMC article.
The αvβ1 integrin plays a critical in vivo role in tissue fibrosis.
Reed NI, Jo H, Chen C, Tsujino K, Arnold TD, DeGrado WF, Sheppard D. Reed NI, et al. Among authors: sheppard d. Sci Transl Med. 2015 May 20;7(288):288ra79. doi: 10.1126/scitranslmed.aaa5094. Sci Transl Med. 2015. PMID: 25995225 Free PMC article.
IL-17A Recruits Rab35 to IL-17R to Mediate PKCα-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility.
Bulek K, Chen X, Parron V, Sundaram A, Herjan T, Ouyang S, Liu C, Majors A, Zepp J, Gao J, Dongre A, Bodaszewska-Lubas M, Echard A, Aronica M, Carman J, Garantziotis S, Sheppard D, Li X. Bulek K, et al. Among authors: sheppard d. J Immunol. 2019 Mar 1;202(5):1540-1548. doi: 10.4049/jimmunol.1801025. Epub 2019 Jan 25. J Immunol. 2019. PMID: 30683702 Free PMC article.
918 results