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405 results

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Page 1
Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket.
Morstein J, Bowcut V, Fernando M, Yang Y, Zhu L, Jenkins ML, Evans JT, Guiley KZ, Peacock DM, Krahnke S, Lin Z, Taran KA, Huang BJ, Stephen AG, Burke JE, Lightstone FC, Shokat KM. Morstein J, et al. Among authors: shokat km. Cell. 2024 Oct 31;187(22):6379-6392.e17. doi: 10.1016/j.cell.2024.08.017. Epub 2024 Sep 9. Cell. 2024. PMID: 39255801 Free PMC article.
Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant.
Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX, Ummadi M, Rojc A, Turner J, Obernier K, Braberg H, Soucheray M, Richards A, Chen KH, Harjai B, Memon D, Hosmillo M, Hiatt J, Jahun A, Goodfellow IG, Fabius JM, Shokat K, Jura N, Verba K, Noursadeghi M, Beltrao P, Swaney DL, Garcia-Sastre A, Jolly C, Towers GJ, Krogan NJ. Thorne LG, et al. Among authors: shokat k. bioRxiv [Preprint]. 2021 Jun 7:2021.06.06.446826. doi: 10.1101/2021.06.06.446826. bioRxiv. 2021. Update in: Nature. 2022 Feb;602(7897):487-495. doi: 10.1038/s41586-021-04352-y. PMID: 34127972 Free PMC article. Updated. Preprint.
Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2.
Tummino TA, Rezelj VV, Fischer B, Fischer A, O'Meara MJ, Monel B, Vallet T, Zhang Z, Alon A, O'Donnell HR, Lyu J, Schadt H, White KM, Krogan NJ, Urban L, Shokat KM, Kruse AC, García-Sastre A, Schwartz O, Moretti F, Vignuzzi M, Pognan F, Shoichet BK. Tummino TA, et al. Among authors: shokat km. bioRxiv [Preprint]. 2021 Mar 24:2021.03.23.436648. doi: 10.1101/2021.03.23.436648. bioRxiv. 2021. PMID: 33791693 Free PMC article. Preprint.
Discovery of Carbohydrate Sulfotransferase Inhibitors from a Kinase-Directed Library We thank Sharon Long and Dave Keating for providing both the NodH sulfotransferase and APS Kinase during our preliminary experiments and Jack Kirsch for numerous helpful conversations. J.I.A. and K.G.B were supported by NIH Molecular Biophysics Training Grant (No. T32GM0895). This research was funded by grants to C.R.B. from the Pew Scholars Program, the W. M. Keck Foundation and the American Cancer Society (Grant No. RPG9700501BE).
Armstrong JI, Portley AR, Chang YT, Nierengarten DM, Cook BN, Bowman KG, Bishop A, Gray NS, Shokat KM, Schultz PG, Bertozzi CR. Armstrong JI, et al. Angew Chem Int Ed Engl. 2000 Apr;39(7):1303-1306. doi: 10.1002/(sici)1521-3773(20000403)39:7<1303::aid-anie1303>3.0.co;2-0. Angew Chem Int Ed Engl. 2000. PMID: 10767039 No abstract available.
Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib.
Leyte-Vidal A, DeFilippis R, Outhwaite IR, Kwan I, Lee JY, Leavitt C, Miller KB, Rea D, Rangwala AM, Lou K, Patel S, Alvarez A, Shokat KM, Bahar I, Seeliger MA, Shah NP. Leyte-Vidal A, et al. Among authors: shokat km. Leukemia. 2024 Sep;38(9):2046-2050. doi: 10.1038/s41375-024-02353-0. Epub 2024 Jul 31. Leukemia. 2024. PMID: 39085402 Free PMC article. No abstract available.
Direct RAS inhibitors turn 10.
Ostrem JML, Peters U, Shokat KM. Ostrem JML, et al. Among authors: shokat km. Nat Chem Biol. 2024 Oct;20(10):1238-1241. doi: 10.1038/s41589-024-01691-5. Nat Chem Biol. 2024. PMID: 39060392 No abstract available.
Acute rapamycin treatment reveals novel mechanisms of behavioral, physiological, and functional dysfunction in a maternal inflammation mouse model of autism and sensory over-responsivity.
Le Belle JE, Condro M, Cepeda C, Oikonomou KD, Tessema K, Dudley L, Schoenfield J, Kawaguchi R, Geschwind D, Silva AJ, Zhang Z, Shokat K, Harris NG, Kornblum HI. Le Belle JE, et al. Among authors: shokat k. bioRxiv [Preprint]. 2024 Jul 11:2024.07.08.602602. doi: 10.1101/2024.07.08.602602. bioRxiv. 2024. PMID: 39026891 Free PMC article. Preprint.
IL-13 and IL-17A Activate β1 Integrin through an NF-kB/Rho kinase/PIP5K1γ pathway to Enhance Force Transmission in Airway Smooth Muscle.
Ngo U, Shi Y, Woodruff P, Shokat K, DeGrado W, Jo H, Sheppard D, Sundaram AB. Ngo U, et al. Among authors: shokat k. bioRxiv [Preprint]. 2024 May 1:2024.05.01.592042. doi: 10.1101/2024.05.01.592042. bioRxiv. 2024. Update in: Proc Natl Acad Sci U S A. 2024 Aug 20;121(34):e2401251121. doi: 10.1073/pnas.2401251121. PMID: 38746410 Free PMC article. Updated. Preprint.
405 results