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Directly monitoring the dynamic in vivo metabolisms of hyperpolarized 13C-oligopeptides.
Kondo Y, Saito Y, Seki T, Takakusagi Y, Koyasu N, Saito K, Morimoto J, Nonaka H, Miyanishi K, Mizukami W, Negoro M, Elhelaly AE, Hyodo F, Matsuo M, Raju N, Swenson RE, Krishna MC, Yamamoto K, Sando S. Kondo Y, et al. Among authors: krishna mc. Sci Adv. 2024 Oct 18;10(42):eadp2533. doi: 10.1126/sciadv.adp2533. Epub 2024 Oct 16. Sci Adv. 2024. PMID: 39413185 Free PMC article.
Targeting NAD+ Metabolism Vulnerability in FH-Deficient Hereditary Leiomyomatosis and Renal Cell Carcinoma with the novel NAMPT Inhibitor OT-82.
Najera SS, Ricketts CJ, Schmidt LS, Medina JI, Saito K, Ileva L, Brender JR, James AM, Peer CJ, Gouker B, Karim BO, Chernova O, Wells C, Wei MH, Yang Y, Zhang X, Klumpp-Thomas C, Travers J, Chen L, Wilson KM, Issaq SH, Figg WD, Difilippantonio S, Kalen JD, Krishna MC, Thomas CJ, Ceribelli M, Heske CM, Crooks DR, Meier JL. Najera SS, et al. Among authors: krishna mc. Mol Cancer Ther. 2024 Oct 14. doi: 10.1158/1535-7163.MCT-24-0225. Online ahead of print. Mol Cancer Ther. 2024. PMID: 39397296
A patient-derived cell model for malignant transformation in IDH-mutant glioma.
Kim O, Sergi Z, Yu G, Yamamoto K, Quezado M, Abdullaev Z, Crooks DR, Kishimoto S, Li Q, Lu P, Blackman B, Andresson T, Wu X, Tran B, Wei JS, Zhang W, Zhang M, Song H, Khan J, Krishna MC, Brender JR, Wu J. Kim O, et al. Among authors: krishna mc. Acta Neuropathol Commun. 2024 Sep 10;12(1):148. doi: 10.1186/s40478-024-01860-6. Acta Neuropathol Commun. 2024. PMID: 39256867 Free PMC article.
In vivo Metabolic Sensing of Hyperpolarized [1-13C]Pyruvate in Mice Using a Recyclable Perfluorinated Iridium Signal Amplification by Reversible Exchange Catalyst.
Ettedgui J, Yamamoto K, Blackman B, Koyasu N, Raju N, Vasalatiy O, Merkle H, Chekmenev EY, Goodson BM, Krishna MC, Swenson RE. Ettedgui J, et al. Among authors: krishna mc. Angew Chem Int Ed Engl. 2024 Oct 21;63(43):e202407349. doi: 10.1002/anie.202407349. Epub 2024 Jul 29. Angew Chem Int Ed Engl. 2024. PMID: 38829568 Free PMC article.
Perfluorinated Iridium Catalyst for Signal Amplification by Reversible Exchange Provides Metal-Free Aqueous Hyperpolarized [1-13C]-Pyruvate.
Ettedgui J, Blackman B, Raju N, Kotler SA, Chekmenev EY, Goodson BM, Merkle H, Woodroofe CC, LeClair CA, Krishna MC, Swenson RE. Ettedgui J, et al. Among authors: krishna mc. J Am Chem Soc. 2024 Jan 10;146(1):946-953. doi: 10.1021/jacs.3c11499. Epub 2023 Dec 28. J Am Chem Soc. 2024. PMID: 38154120 Free PMC article.
243 results