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Loss of HD-PTP function results in lipodystrophy, defective cellular signaling and altered lipid homeostasis.
Schultz DF, Davies BA, Payne JA, Martin CP, Minard AY, Childs BG, Zhang C, Jeganathan KB, Sturmlechner I, White TA, de Bruin A, Harkema L, Chen H, Davies MA, Jachim S, LeBrasseur NK, Piper RC, Li H, Baker DJ, van Deursen J, Billadeau DD, Katzmann DJ. Schultz DF, et al. Among authors: lebrasseur nk. J Cell Sci. 2024 Sep 15;137(18):jcs262032. doi: 10.1242/jcs.262032. Epub 2024 Sep 27. J Cell Sci. 2024. PMID: 39155850
Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles.
List EO, Berryman DE, Funk K, Jara A, Kelder B, Wang F, Stout MB, Zhi X, Sun L, White TA, LeBrasseur NK, Pirtskhalava T, Tchkonia T, Jensen EA, Zhang W, Masternak MM, Kirkland JL, Miller RA, Bartke A, Kopchick JJ. List EO, et al. Among authors: lebrasseur nk. Endocrinology. 2014 May;155(5):1793-805. doi: 10.1210/en.2013-2086. Epub 2014 Feb 11. Endocrinology. 2014. PMID: 24517230 Free PMC article.
TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess.
Idrissova L, Malhi H, Werneburg NW, LeBrasseur NK, Bronk SF, Fingas C, Tchkonia T, Pirtskhalava T, White TA, Stout MB, Hirsova P, Krishnan A, Liedtke C, Trautwein C, Finnberg N, El-Deiry WS, Kirkland JL, Gores GJ. Idrissova L, et al. Among authors: lebrasseur nk. J Hepatol. 2015 May;62(5):1156-63. doi: 10.1016/j.jhep.2014.11.033. Epub 2014 Nov 28. J Hepatol. 2015. PMID: 25445398 Free PMC article.
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age.
Xu M, Tchkonia T, Ding H, Ogrodnik M, Lubbers ER, Pirtskhalava T, White TA, Johnson KO, Stout MB, Mezera V, Giorgadze N, Jensen MD, LeBrasseur NK, Kirkland JL. Xu M, et al. Among authors: lebrasseur nk. Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6301-10. doi: 10.1073/pnas.1515386112. Epub 2015 Nov 2. Proc Natl Acad Sci U S A. 2015. PMID: 26578790 Free PMC article.
185 results