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Targeting host inducible-heat shock protein 70 with PES-Cl is a promising antiviral strategy against SARS-CoV-2 infection and pathogenesis.
Joshi P, Garg S, Mani S, Shoaib R, Jakhar K, Almuqdadi HTA, Sonar S, Marothia M, Behl A, Biswas S, Singhal J, Kahlon AK, Shevtsov M, Abid M, Garg P, Ranganathan A, Singh S. Joshi P, et al. Among authors: jakhar k. Int J Biol Macromol. 2024 Nov;279(Pt 1):135069. doi: 10.1016/j.ijbiomac.2024.135069. Epub 2024 Aug 24. Int J Biol Macromol. 2024. PMID: 39187102
Targeting DPP4-RBD interactions by sitagliptin and linagliptin delivers a potential host-directed therapy against pan-SARS-CoV-2 infections.
Mani S, Kaur A, Jakhar K, Kumari G, Sonar S, Kumar A, Das S, Kumar S, Kumar V, Kundu R, Pandey AK, Singh UP, Majumdar T. Mani S, et al. Among authors: jakhar k. Int J Biol Macromol. 2023 Aug 1;245:125444. doi: 10.1016/j.ijbiomac.2023.125444. Epub 2023 Jun 27. Int J Biol Macromol. 2023. PMID: 37385308 Free PMC article.
Comparative Immunomodulatory Evaluation of the Receptor Binding Domain of the SARS-CoV-2 Spike Protein; a Potential Vaccine Candidate Which Imparts Potent Humoral and Th1 Type Immune Response in a Mouse Model.
Shrivastava T, Singh B, Rizvi ZA, Verma R, Goswami S, Vishwakarma P, Jakhar K, Sonar S, Mani S, Bhattacharyya S, Awasthi A, Surjit M. Shrivastava T, et al. Among authors: jakhar k. Front Immunol. 2021 May 24;12:641447. doi: 10.3389/fimmu.2021.641447. eCollection 2021. Front Immunol. 2021. PMID: 34108961 Free PMC article.
Non-neutralizing SARS CoV-2 directed polyclonal antibodies demonstrate cross-reactivity with the HA glycans of influenza virus.
Murugavelu P, Perween R, Shrivastava T, Singh V, Ahmad Parray H, Singh S, Chiranjivi AK, Thiruvengadam R, Singh S, Yadav N, Jakhar K, Sonar S, Mani S, Bhattacharyya S, Sharma C, Vishwakarma P, Khatri R, Kumar Panchal A, Das S, Ahmed S, Samal S, Kshetrapal P, Bhatnagar S, Luthra K, Kumar R. Murugavelu P, et al. Among authors: jakhar k. Int Immunopharmacol. 2021 Oct;99:108020. doi: 10.1016/j.intimp.2021.108020. Epub 2021 Jul 29. Int Immunopharmacol. 2021. PMID: 34426117 Free PMC article.
The SARS CoV-2 spike directed non-neutralizing polyclonal antibodies cross-react with Human immunodeficiency virus (HIV-1) gp41.
Perween R, PraveenKumar M, Shrivastava T, Parray HA, Singh V, Singh S, Chiranjivi A, Jakhar K, Sonar S, Tiwari M, Reema, Panchal AK, Sharma C, Rathore DK, Ahamed S, Samal S, Mani S, Bhattacharyya S, Das S, Luthra K, Kumar R. Perween R, et al. Among authors: jakhar k. Int Immunopharmacol. 2021 Dec;101(Pt B):108187. doi: 10.1016/j.intimp.2021.108187. Epub 2021 Sep 28. Int Immunopharmacol. 2021. PMID: 34649114 Free PMC article.
A broadly neutralizing monoclonal antibody overcomes the mutational landscape of emerging SARS-CoV-2 variants of concern.
Parray HA, Narayanan N, Garg S, Rizvi ZA, Shrivastava T, Kushwaha S, Singh J, Murugavelu P, Anantharaj A, Mehdi F, Raj N, Singh S, Dandotiya J, Lukose A, Jamwal D, Kumar S, Chiranjivi AK, Dhyani S, Mishra N, Kumar S, Jakhar K, Sonar S, Panchal AK, Tripathy MR, Chowdhury SR, Ahmed S, Samal S, Mani S, Bhattacharyya S, Das S, Sinha S, Luthra K, Batra G, Sehgal D, Medigeshi GR, Sharma C, Awasthi A, Garg PK, Nair DT, Kumar R. Parray HA, et al. Among authors: jakhar k. PLoS Pathog. 2022 Dec 12;18(12):e1010994. doi: 10.1371/journal.ppat.1010994. eCollection 2022 Dec. PLoS Pathog. 2022. PMID: 36508467 Free PMC article.
Characterization of a broadly cross reactive tetravalent human monoclonal antibody, recognizing conformational epitopes in receptor binding domain of SARS-CoV-2.
Garg S, Raj N, Lukose A, Jamwal D, Parray HA, Kumar S, Dhyani S, Jakhar K, Sonar S, Tiwari M, Reema, Mani S, Bhattacharyya S, Sharma C, Shrivastava T, Kumar R. Garg S, et al. Among authors: jakhar k. 3 Biotech. 2022 Sep;12(9):202. doi: 10.1007/s13205-022-03272-6. Epub 2022 Aug 2. 3 Biotech. 2022. PMID: 35928502 Free PMC article.
Trends of humoral immune responses to heterologous antigenic exposure due to vaccination & omicron SARS-CoV-2 infection: Implications for boosting.
Batra G, Murugesan DR, Raghavan S, Chattopadhyay S, Mehdi F, Ayushi, Gosain M, Singh S, Das SJ, Deshpande S, Sonar S, Jakhar K, Bhattacharya J, Mani S, Pandey AK, Sankalp, Goswami S, Das A, Dwivedi T, Sharma N, Kumar S, Sharma P, Kapoor S, Kshetrapa P, Wadhwa N, Thiruvengadam R, Kumar R, Gupta R, Garg PK, Bhatnagar S. Batra G, et al. Among authors: jakhar k. Indian J Med Res. 2023 Jun;157(6):509-518. doi: 10.4103/ijmr.ijmr_2521_22. Indian J Med Res. 2023. PMID: 37322634 Free PMC article.
A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 Delta variant.
Hingankar N, Deshpande S, Das P, Rizvi ZA, Wibmer CK, Mashilo P, Ansari MY, Burns A, Barman S, Zhao F, Mukherjee S, Torres JL, Chattopadhyay S, Mehdi F, Sutar J, Rathore DK, Pargai K, Singh J, Sonar S, Jakhar K, Dandotiya J, Bhattacharyya S, Mani S, Samal S, Singh S, Kshetrapal P, Thiruvengadam R, Batra G, Medigeshi G, Ward AB, Bhatnagar S, Awasthi A, Sok D, Bhattacharya J. Hingankar N, et al. Among authors: jakhar k. PLoS Pathog. 2022 Apr 28;18(4):e1010465. doi: 10.1371/journal.ppat.1010465. eCollection 2022 Apr. PLoS Pathog. 2022. PMID: 35482816 Free PMC article.
High failure rate of ChAdOx1-nCoV19 immunization against asymptomatic infection in healthcare workers during a Delta variant surge.
Ujjainiya R, Tyagi A, Sardana V, Naushin S, Bhatheja N, Kumar K, Barman J, Prakash S, Kutum R, Bhaskar AK, Singh P, Chaudhary K, Loomba M, Khanna Y, Walecha C, Ahmed R, Yadav A, Bajaj A, Malik G, Qureshi S, Waghdhare S, Siddiqui S, Trehan KK, Mani M, Dang R, Das P, Dougall P, Mahajan M, Sonar S, Jakhar K, Kumar R, Tiwari M, Mani S, Bhattacharyya S, Budhiraja S, Agrawal A, Dash D, Jha S, Sengupta S. Ujjainiya R, et al. Among authors: jakhar k. Nat Commun. 2022 Apr 1;13(1):1726. doi: 10.1038/s41467-022-29404-3. Nat Commun. 2022. PMID: 35365648 Free PMC article.
44 results