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Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage.
Zerbib J, Ippolito MR, Eliezer Y, De Feudis G, Reuveni E, Savir Kadmon A, Martin S, Viganò S, Leor G, Berstler J, Muenzner J, Mülleder M, Campagnolo EM, Shulman ED, Chang T, Rubolino C, Laue K, Cohen-Sharir Y, Scorzoni S, Taglietti S, Ratti A, Stossel C, Golan T, Nicassio F, Ruppin E, Ralser M, Vazquez F, Ben-David U, Santaguida S. Zerbib J, et al. Among authors: scorzoni s. Nat Commun. 2024 Sep 9;15(1):7772. doi: 10.1038/s41467-024-52176-x. Nat Commun. 2024. PMID: 39251587 Free PMC article.
Increased RNA and protein degradation is required for counteracting transcriptional burden and proteotoxic stress in human aneuploid cells.
Ippolito MR, Zerbib J, Eliezer Y, Reuveni E, Vigano S, De Feudis G, Shulman ED, Savir Kadmon A, Slutsky R, Chang T, Campagnolo EM, Taglietti S, Scorzoni S, Gianotti S, Martin S, Muenzner J, Mulleder M, Rozenblum N, Rubolino C, Ben-Yishay T, Laue K, Cohen-Sharir Y, Vigorito I, Nicassio F, Ruppin E, Ralser M, Vazquez F, Santaguida S, Ben-David U. Ippolito MR, et al. Among authors: scorzoni s. Cancer Discov. 2024 Sep 9. doi: 10.1158/2159-8290.CD-23-0309. Online ahead of print. Cancer Discov. 2024. PMID: 39247952
A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements.
Martin S, Scorzoni S, Cordone S, Mazzagatti A, Beznoussenko GV, Gunn AL, Di Bona M, Eliezer Y, Leor G, Ben-Yishay T, Loffreda A, Cancila V, Rainone MC, Ippolito MR, Martis V, Bedin F, Garrè M, Vaites LP, Vasapolli P, Polo S, Parazzoli D, Tripodo C, Mironov AA, Cuomo A, Ben-David U, Bakhoum SF, Hatch EM, Ly P, Santaguida S. Martin S, et al. Among authors: scorzoni s. Science. 2024 Aug 30;385(6712):eadj7446. doi: 10.1126/science.adj7446. Epub 2024 Aug 30. Science. 2024. PMID: 39208097
A substrate-based ontology for human solute carriers.
Meixner E, Goldmann U, Sedlyarov V, Scorzoni S, Rebsamen M, Girardi E, Superti-Furga G. Meixner E, et al. Among authors: scorzoni s. Mol Syst Biol. 2020 Jul;16(7):e9652. doi: 10.15252/msb.20209652. Mol Syst Biol. 2020. PMID: 32697042 Free PMC article.
TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9.
Heinz LX, Lee J, Kapoor U, Kartnig F, Sedlyarov V, Papakostas K, César-Razquin A, Essletzbichler P, Goldmann U, Stefanovic A, Bigenzahn JW, Scorzoni S, Pizzagalli MD, Bensimon A, Müller AC, King FJ, Li J, Girardi E, Mbow ML, Whitehurst CE, Rebsamen M, Superti-Furga G. Heinz LX, et al. Among authors: scorzoni s. Nature. 2020 May;581(7808):316-322. doi: 10.1038/s41586-020-2282-0. Epub 2020 May 13. Nature. 2020. PMID: 32433612 Free PMC article.
Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking.
Fauster A, Rebsamen M, Willmann KL, César-Razquin A, Girardi E, Bigenzahn JW, Schischlik F, Scorzoni S, Bruckner M, Konecka J, Hörmann K, Heinz LX, Boztug K, Superti-Furga G. Fauster A, et al. Among authors: scorzoni s. Cell Death Differ. 2019 Jun;26(6):1138-1155. doi: 10.1038/s41418-018-0192-6. Epub 2018 Sep 20. Cell Death Differ. 2019. PMID: 30237509 Free PMC article.
A time-resolved molecular map of the macrophage response to VSV infection.
Kandasamy RK, Vladimer GI, Snijder B, Müller AC, Rebsamen M, Bigenzahn JW, Moskovskich A, Sabler M, Stefanovic A, Scorzoni S, Brückner M, Penz T, Cleary C, Kralovics R, Colinge J, Bennett KL, Superti-Furga G. Kandasamy RK, et al. Among authors: scorzoni s. NPJ Syst Biol Appl. 2016 Oct 27;2:16027. doi: 10.1038/npjsba.2016.27. eCollection 2016. NPJ Syst Biol Appl. 2016. PMID: 28725479 Free PMC article.
17 results