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An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function.
Kambali M, Li Y, Unichenko P, Feria Pliego JA, Yadav R, Liu J, McGuinness P, Cobb JG, Wang M, Nagarajan R, Lyu J, Vongsouthi V, Jackson CJ, Engin E, Coyle JT, Shin J, Hodgson NW, Hensch TK, Talkowski ME, Homanics GE, Bolshakov VY, Henneberger C, Rudolph U. Kambali M, et al. Among authors: hensch tk. Mol Psychiatry. 2024 Aug 30. doi: 10.1038/s41380-024-02711-5. Online ahead of print. Mol Psychiatry. 2024. PMID: 39210012
Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia.
Steullet P, Cabungcal JH, Coyle J, Didriksen M, Gill K, Grace AA, Hensch TK, LaMantia AS, Lindemann L, Maynard TM, Meyer U, Morishita H, O'Donnell P, Puhl M, Cuenod M, Do KQ. Steullet P, et al. Among authors: hensch tk. Mol Psychiatry. 2017 Jul;22(7):936-943. doi: 10.1038/mp.2017.47. Epub 2017 Mar 21. Mol Psychiatry. 2017. PMID: 28322275 Free PMC article.
Deletion of Neuronal GLT-1 in Mice Reveals Its Role in Synaptic Glutamate Homeostasis and Mitochondrial Function.
McNair LF, Andersen JV, Aldana BI, Hohnholt MC, Nissen JD, Sun Y, Fischer KD, Sonnewald U, Nyberg N, Webster SC, Kapur K, Rimmele TS, Barone I, Hawks-Mayer H, Lipton JO, Hodgson NW, Hensch TK, Aoki CJ, Rosenberg PA, Waagepetersen HS. McNair LF, et al. Among authors: hensch tk. J Neurosci. 2019 Jun 19;39(25):4847-4863. doi: 10.1523/JNEUROSCI.0894-18.2019. Epub 2019 Mar 29. J Neurosci. 2019. PMID: 30926746 Free PMC article.
α2-containing γ-aminobutyric acid type A receptors promote stress resiliency in male mice.
Benham RS, Choi C, Hodgson NW, Hewage NB, Kastli R, Donahue RJ, Muschamp JW, Engin E, Carlezon WA Jr, Hensch TK, Rudolph U. Benham RS, et al. Among authors: hensch tk. Neuropsychopharmacology. 2021 Nov;46(12):2197-2206. doi: 10.1038/s41386-021-01144-w. Epub 2021 Aug 18. Neuropsychopharmacology. 2021. PMID: 34408277 Free PMC article.
N-acetylcysteine treatment mitigates loss of cortical parvalbumin-positive interneuron and perineuronal net integrity resulting from persistent oxidative stress in a rat TBI model.
Hameed MQ, Hodgson N, Lee HHC, Pascual-Leone A, MacMullin PC, Jannati A, Dhamne SC, Hensch TK, Rotenberg A. Hameed MQ, et al. Among authors: hensch tk. Cereb Cortex. 2023 Mar 21;33(7):4070-4084. doi: 10.1093/cercor/bhac327. Cereb Cortex. 2023. PMID: 36130098 Free PMC article.
Sleep-sensitive dopamine receptor expression in male mice underlies attention deficits after a critical period of early adversity.
Makino Y, Hodgson NW, Doenier E, Serbin AV, Osada K, Artoni P, Dickey M, Sullivan B, Potter-Dickey A, Komanchuk J, Sekhon B, Letourneau N, Ryan ND, Trauth J, Cameron JL, Hensch TK. Makino Y, et al. Among authors: hensch tk. Sci Transl Med. 2024 Oct 9;16(768):eadh9763. doi: 10.1126/scitranslmed.adh9763. Epub 2024 Oct 9. Sci Transl Med. 2024. PMID: 39383245
Specific GABAA circuits for visual cortical plasticity.
Fagiolini M, Fritschy JM, Löw K, Möhler H, Rudolph U, Hensch TK. Fagiolini M, et al. Among authors: hensch tk. Science. 2004 Mar 12;303(5664):1681-3. doi: 10.1126/science.1091032. Science. 2004. PMID: 15017002
Increase in Seizure Susceptibility After Repetitive Concussion Results from Oxidative Stress, Parvalbumin-Positive Interneuron Dysfunction and Biphasic Increases in Glutamate/GABA Ratio.
MacMullin P, Hodgson N, Damar U, Lee HHC, Hameed MQ, Dhamne SC, Hyde D, Conley GM, Morriss N, Qiu J, Mannix R, Hensch TK, Rotenberg A. MacMullin P, et al. Among authors: hensch tk. Cereb Cortex. 2020 Nov 3;30(12):6108-6120. doi: 10.1093/cercor/bhaa157. Cereb Cortex. 2020. PMID: 32676666 Free PMC article.
114 results