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Therapeutic targeting of Syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers.
Takeda M, Theardy MS, Sorokin A, Coker O, Kanikarla P, Chen S, Yang Z, Nguyen P, Wei Y, Yao J, Wang X, Yan L, Jin Y, Cai Y, Paku M, Chen Z, Li KZ, Citron F, Tomihara H, Gao S, Deem AK, Zhao J, Wang H, Hanash S, DePinho RA, Maitra A, Draetta GF, Ying H, Kopetz S, Yao W. Takeda M, et al. Among authors: wang x, wang h. bioRxiv [Preprint]. 2024 Aug 8:2024.08.06.606865. doi: 10.1101/2024.08.06.606865. bioRxiv. 2024. PMID: 39211217 Free PMC article. Preprint.
KRAS inhibition activates an actionable CD24 'don't eat me' signal in pancreas cancer.
Wei Y, Liu M, Yen EY, Yao J, Nguyen PT, Wang X, Yang Z, Yousef A, Pan D, Jin Y, Theady MS, Park J, Cai Y, Takeda M, Vasquez M, Zhou Y, Zhao H, Viale A, Wang H, Zhao D, DePinho RA, Yao W, Ying H. Wei Y, et al. Among authors: wang x, wang h. bioRxiv [Preprint]. 2023 Sep 23:2023.09.21.558891. doi: 10.1101/2023.09.21.558891. bioRxiv. 2023. PMID: 37790498 Free PMC article. Preprint.
WRAD core perturbation impairs DNA replication fidelity promoting immunoediting in pancreatic cancer.
Citron F, Ho IL, Balestrieri C, Liu Z, Yen EY, Cecchetto L, Perelli L, Zhang L, Montanez LC, Blazanin N, Dyke CA, Shah R, Attanasio S, Srinivasan S, Chen KC, Chen Z, Scognamiglio I, Pham N, Khan H, Jiang S, Pan J, Vanderkruk B, Leung CS, Mattohti M, Rai K, Chu Y, Wang L, Gao S, Deem AK, Carugo A, Wang H, Yao W, Tonon G, Xiong Y, Lorenzi PL, Bonini C, Anna Zal M, Hoffman BG, Heffernan T, Giuliani V, Jeter CR, Lissanu Y, Genovese G, Pilato MD, Viale A, Draetta GF. Citron F, et al. Among authors: wang h, wang l. bioRxiv [Preprint]. 2024 Oct 24:2024.10.21.619543. doi: 10.1101/2024.10.21.619543. bioRxiv. 2024. PMID: 39484624 Free PMC article. Preprint.
All-trans retinoic acid-mediated ADAR1 degradation synergizes with PD-1 blockade to suppress pancreatic cancer.
Li CF, Bai LY, Wei Y, Lee HH, Yang R, Yao J, Wang H, Wang YN, Chang WC, Shen YC, Wang SC, Chou CW, Fu J, Ling J, Chu YY, Chiu CF, Wang M, Yu D, Chiao PJ, Liang H, Maitra A, Ying H, Hung MC. Li CF, et al. Among authors: wang h, wang sc, wang yn, wang m. bioRxiv [Preprint]. 2024 Oct 23:2024.10.20.619300. doi: 10.1101/2024.10.20.619300. bioRxiv. 2024. PMID: 39484589 Free PMC article. Preprint.
Antigen-presenting type-I conventional dendritic cells facilitate curative checkpoint blockade immunotherapy in pancreatic cancer.
Mahadevan KK, Dyevoich AM, Chen Y, Li B, Sugimoto H, Sockwell AM, McAndrews KM, Wang H, Shalapour S, Watowich SS, Kalluri R. Mahadevan KK, et al. Among authors: wang h. bioRxiv [Preprint]. 2023 Mar 6:2023.03.05.531191. doi: 10.1101/2023.03.05.531191. bioRxiv. 2023. Update in: Science. 2024 Jun 28;384(6703):eadh4567. doi: 10.1126/science.adh4567 PMID: 36945457 Free PMC article. Updated. Preprint.
Netrin G1 Ligand is a new stromal immunomodulator that promotes pancreatic cancer.
Vendramini-Costa DB, Francescone R, Franco-Barraza J, Luong T, Graves M, de Aquino AM, Steele N, Gardiner JC, Dos Santos SAA, Ogier C, Malloy E, Borghaei L, Martinez E, Zhigarev DI, Tan Y, Lee H, Zhou Y, Cai KQ, Klein-Szanto AJ, Wang H, Andrake M, Dunbrack RL, Campbell K, Cukierman E. Vendramini-Costa DB, et al. Among authors: wang h. bioRxiv [Preprint]. 2024 May 18:2024.05.15.594354. doi: 10.1101/2024.05.15.594354. bioRxiv. 2024. PMID: 38798370 Free PMC article. Preprint.
CDH1 loss promotes diffuse-type gastric cancer tumorigenesis via epigenetic reprogramming and immune evasion.
Zou G, Huang Y, Zhang S, Ko KP, Kim B, Zhang J, Venkatesan V, Pizzi MP, Fan Y, Jun S, Niu N, Wang H, Song S, Ajani JA, Park JI. Zou G, et al. Among authors: wang h. bioRxiv [Preprint]. 2023 Oct 11:2023.03.23.533976. doi: 10.1101/2023.03.23.533976. bioRxiv. 2023. Update in: J Exp Med. 2024 Apr 1;221(4):e20230561. doi: 10.1084/jem.20230561 PMID: 36993615 Free PMC article. Updated. Preprint.
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