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CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes.
Mitchell JS, Spanier JA, Dwyer AJ, Knutson TP, Alkhatib MH, Qian G, Weno ME, Chen Y, Shaheen ZR, Tucker CG, Kangas TO, Morales MS, Silva N, Kaisho T, Farrar MA, Fife BT. Mitchell JS, et al. Immunity. 2024 Oct 8;57(10):2399-2415.e8. doi: 10.1016/j.immuni.2024.07.024. Epub 2024 Aug 29. Immunity. 2024. PMID: 39214091
Programmed Death-1 Restrains the Germinal Center in Type 1 Diabetes.
Martinov T, Swanson LA, Breed ER, Tucker CG, Dwyer AJ, Johnson JK, Mitchell JS, Sahli NL, Wilson JC, Singh LM, Hogquist KA, Spanier JA, Fife BT. Martinov T, et al. Among authors: mitchell js. J Immunol. 2019 Aug 15;203(4):844-852. doi: 10.4049/jimmunol.1801535. Epub 2019 Jul 19. J Immunol. 2019. PMID: 31324724 Free PMC article.
Insulin B peptide-MHC class II-specific chimeric antigen receptor-Tregs prevent autoimmune diabetes.
Spanier JA, Fung V, Wardell CM, Alkhatib MH, Chen Y, Swanson LA, Dwyer AJ, Weno ME, Silva N, Mitchell JS, Orban PC, Mojibian M, Verchere CB, Fife BT, Levings MK. Spanier JA, et al. Among authors: mitchell js. bioRxiv [Preprint]. 2023 Feb 24:2023.02.23.529737. doi: 10.1101/2023.02.23.529737. bioRxiv. 2023. Update in: J Clin Invest. 2023 Sep 15;133(18):e168601. doi: 10.1172/JCI168601 PMID: 36865264 Free PMC article. Updated. Preprint.
T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells.
Beura LK, Wijeyesinghe S, Thompson EA, Macchietto MG, Rosato PC, Pierson MJ, Schenkel JM, Mitchell JS, Vezys V, Fife BT, Shen S, Masopust D. Beura LK, et al. Among authors: mitchell js. Immunity. 2018 Feb 20;48(2):327-338.e5. doi: 10.1016/j.immuni.2018.01.015. Immunity. 2018. PMID: 29466758 Free PMC article.
Adoptive T Cell Therapy with IL-12-Preconditioned Low-Avidity T Cells Prevents Exhaustion and Results in Enhanced T Cell Activation, Enhanced Tumor Clearance, and Decreased Risk for Autoimmunity.
Tucker CG, Mitchell JS, Martinov T, Burbach BJ, Beura LK, Wilson JC, Dwyer AJ, Singh LM, Mescher MF, Fife BT. Tucker CG, et al. Among authors: mitchell js. J Immunol. 2020 Sep 1;205(5):1449-1460. doi: 10.4049/jimmunol.2000007. Epub 2020 Jul 31. J Immunol. 2020. PMID: 32737148 Free PMC article.
188 results