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Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH.
Vandyck K, McGowan DC, Luong XG, Stevens SK, Jekle A, Gupta K, Misner DL, Chanda S, Serebryany V, Welch M, Hu H, Lv Z, Williams C, Maskos K, Lammens A, Stoycheva AD, Lin TI, Blatt LM, Beigelman LN, Symons JA, Raboisson P, Deval J. Vandyck K, et al. Among authors: hu h. J Med Chem. 2024 Sep 12;67(17):14840-14851. doi: 10.1021/acs.jmedchem.4c01029. Epub 2024 Sep 2. J Med Chem. 2024. PMID: 39221768
Discovery of a novel series of selective macrocyclic PKCTheta inhibitors.
Crosignani S, Campos S, Bouix-Peter C, Harris C, Talbot E, Hu H, Wang S, Maclean J, Zanelli U, Taylor S, Foote K, Hacini-Rachinel F, Nicodeme E, Julia V. Crosignani S, et al. Among authors: hu h. Bioorg Med Chem Lett. 2024 Mar 1;100:129630. doi: 10.1016/j.bmcl.2024.129630. Epub 2024 Feb 1. Bioorg Med Chem Lett. 2024. PMID: 38307441
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