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2,214 results

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Discovery of potent SARS-CoV-2 nsp3 macrodomain inhibitors uncovers lack of translation to cellular antiviral response.
Lee AA, Amick I, Aschenbrenner JC, Barr HM, Benjamin J, Brandis A, Cohen G, Diaz-Tapia R, Duberstein S, Dixon J, Cousins D, Fairhead M, Fearon D, Frick J, Gayvert J, Godoy AS, Griffin EJ, Huber K, Koekemoer L, Lahav N, Marples PG, McGovern BL, Mehlman T, Robinson MC, Singh U, Szommer T, Tomlinson CWE, Vargo T, von Delft F, Wang S, White K, Williams E, Winokan M. Lee AA, et al. Among authors: singh u. bioRxiv [Preprint]. 2024 Aug 21:2024.08.19.608619. doi: 10.1101/2024.08.19.608619. bioRxiv. 2024. PMID: 39229055 Free PMC article. Preprint.
Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist.
Balıkçı E, Marques AMC, Bauer LG, Seupel R, Bennett J, Raux B, Buchan K, Simelis K, Singh U, Rogers C, Ward J, Cheng C, Szommer T, Schützenhofer K, Elkins JM, Sloman DL, Ahel I, Fedorov O, Brennan PE, Huber KVM. Balıkçı E, et al. Among authors: singh u. J Med Chem. 2024 May 9;67(9):7245-7259. doi: 10.1021/acs.jmedchem.4c00072. Epub 2024 Apr 18. J Med Chem. 2024. PMID: 38635563 Free PMC article.
Previse preterm birth in early pregnancy through vaginal microbiome signatures using metagenomics and dipstick assays.
Talukdar D, Sarkar M, Ahrodia T, Kumar S, De D, Nath S, Jana P, Verma J, Mehta O, Kothidar A, Yodhaanjali JR, Sharma K, Bakshi S, Singh U, Kshetrapal P, Wadhwa N, Thiruvengadam R; Garbh-Ini study group; Nair GB, Bhatnagar S, Mukherjee S, Das B. Talukdar D, et al. Among authors: singh u. iScience. 2024 Oct 23;27(11):111238. doi: 10.1016/j.isci.2024.111238. eCollection 2024 Nov 15. iScience. 2024. PMID: 39569373 Free PMC article.
Management of aseptic nonunions of bicondylar tibial plateau fractures.
Hresko AM, Dekhne M, Grisdela P Jr, Challa S, Guild T, Singh UM, Weaver MJ, Stenquist D, von Keudell A. Hresko AM, et al. Among authors: singh um. Eur J Orthop Surg Traumatol. 2024 Nov 21;35(1):17. doi: 10.1007/s00590-024-04126-y. Eur J Orthop Surg Traumatol. 2024. PMID: 39567407
Studies of Structure-Activity Relationship of 2-(Pyrrolidin-1ylmethyl)-1H-pyrrole-Based ST2 Inhibitors and Their Inhibition of Mast Cells Activation.
Yuan X, Rech JC, Ramaraju A, Patil AD, Rajanayake K, Yuan H, Kazemi Sabzvar M, Mandal M, Cho EB, Wen B, Jiang J, Leo MD, Singh UP, Sun D, Yang CY. Yuan X, et al. Among authors: singh up. ACS Med Chem Lett. 2024 Oct 18;15(11):2053-2059. doi: 10.1021/acsmedchemlett.4c00459. eCollection 2024 Nov 14. ACS Med Chem Lett. 2024. PMID: 39563831
2,214 results