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Discovery of potent SARS-CoV-2 nsp3 macrodomain inhibitors uncovers lack of translation to cellular antiviral response.
Lee AA, Amick I, Aschenbrenner JC, Barr HM, Benjamin J, Brandis A, Cohen G, Diaz-Tapia R, Duberstein S, Dixon J, Cousins D, Fairhead M, Fearon D, Frick J, Gayvert J, Godoy AS, Griffin EJ, Huber K, Koekemoer L, Lahav N, Marples PG, McGovern BL, Mehlman T, Robinson MC, Singh U, Szommer T, Tomlinson CWE, Vargo T, von Delft F, Wang S, White K, Williams E, Winokan M. Lee AA, et al. Among authors: wang s. bioRxiv [Preprint]. 2024 Aug 21:2024.08.19.608619. doi: 10.1101/2024.08.19.608619. bioRxiv. 2024. PMID: 39229055 Free PMC article. Preprint.
Crystallographic fragment screening delivers diverse chemical scaffolds for Zika virus NS2B-NS3 protease inhibitor development.
Ni X, Godoy AS, Marples PG, Fairhead M, Balcomb BH, Ferla MP, Tomlinson CWE, Wang S, Giroud C, Aschenbrenner JC, Lithgo RM, Winokan M, Chandran AV, Thompson W, Xavier MA, Williams EP, Walsh M, Fearon D, Koekemoer L, von Delft F. Ni X, et al. Among authors: wang s. bioRxiv [Preprint]. 2024 Apr 29:2024.04.29.591502. doi: 10.1101/2024.04.29.591502. bioRxiv. 2024. PMID: 38746305 Free PMC article. Preprint.
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