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HSF1 is a prognostic determinant and therapeutic target in intrahepatic cholangiocarcinoma.
Cigliano A, Gigante I, Serra M, Vidili G, Simile MM, Steinmann S, Urigo F, Cossu E, Pes GM, Dore MP, Ribback S, Milia EP, Pizzuto E, Mancarella S, Che L, Pascale RM, Giannelli G, Evert M, Chen X, Calvisi DF. Cigliano A, et al. J Exp Clin Cancer Res. 2024 Sep 6;43(1):253. doi: 10.1186/s13046-024-03177-7. J Exp Clin Cancer Res. 2024. PMID: 39243039 Free PMC article.
Role of the Notch signaling in cholangiocarcinoma.
Cigliano A, Wang J, Chen X, Calvisi DF. Cigliano A, et al. Expert Opin Ther Targets. 2017 May;21(5):471-483. doi: 10.1080/14728222.2017.1310842. Epub 2017 Mar 30. Expert Opin Ther Targets. 2017. PMID: 28326864 Review.
Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice.
Zhang S, Song X, Cao D, Xu Z, Fan B, Che L, Hu J, Chen B, Dong M, Pilo MG, Cigliano A, Evert K, Ribback S, Dombrowski F, Pascale RM, Cossu A, Vidili G, Porcu A, Simile MM, Pes GM, Giannelli G, Gordan J, Wei L, Evert M, Cong W, Calvisi DF, Chen X. Zhang S, et al. Among authors: cigliano a. J Hepatol. 2017 Dec;67(6):1194-1203. doi: 10.1016/j.jhep.2017.07.006. Epub 2017 Jul 19. J Hepatol. 2017. PMID: 28733220 Free PMC article.
Combined CDK4/6 and Pan-mTOR Inhibition Is Synergistic Against Intrahepatic Cholangiocarcinoma.
Song X, Liu X, Wang H, Wang J, Qiao Y, Cigliano A, Utpatel K, Ribback S, Pilo MG, Serra M, Gordan JD, Che L, Zhang S, Cossu A, Porcu A, Pascale RM, Dombrowski F, Hu H, Calvisi DF, Evert M, Chen X. Song X, et al. Among authors: cigliano a. Clin Cancer Res. 2019 Jan 1;25(1):403-413. doi: 10.1158/1078-0432.CCR-18-0284. Epub 2018 Jul 3. Clin Cancer Res. 2019. PMID: 30084835 Free PMC article.
SNAI1 Promotes the Cholangiocellular Phenotype, but not Epithelial-Mesenchymal Transition, in a Murine Hepatocellular Carcinoma Model.
Xu M, Wang J, Xu Z, Li R, Wang P, Shang R, Cigliano A, Ribback S, Solinas A, Pes GM, Evert K, Wang H, Song X, Zhang S, Che L, Pascale RM, Calvisi DF, Liu Q, Chen X. Xu M, et al. Among authors: cigliano a. Cancer Res. 2019 Nov 1;79(21):5563-5574. doi: 10.1158/0008-5472.CAN-18-3750. Epub 2019 Aug 5. Cancer Res. 2019. PMID: 31383647 Free PMC article.
The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease.
Cigliano A, Zhang S, Ribback S, Steinmann S, Sini M, Ament CE, Utpatel K, Song X, Wang J, Pilo MG, Berger F, Wang H, Tao J, Li X, Pes GM, Mancarella S, Giannelli G, Dombrowski F, Evert M, Calvisi DF, Chen X, Evert K. Cigliano A, et al. J Exp Clin Cancer Res. 2022 Jun 3;41(1):192. doi: 10.1186/s13046-022-02394-2. J Exp Clin Cancer Res. 2022. PMID: 35655220 Free PMC article.
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