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The islet tissue plasminogen activator/plasmin system is upregulated with human islet amyloid polypeptide aggregation and protects beta cells from aggregation-induced toxicity.
Esser N, Hogan MF, Templin AT, Akter R, Fountaine BS, Castillo JJ, El-Osta A, Manathunga L, Zhyvoloup A, Raleigh DP, Zraika S, Hull RL, Kahn SE. Esser N, et al. Among authors: fountaine bs. Diabetologia. 2024 Sep;67(9):1897-1911. doi: 10.1007/s00125-024-06161-0. Epub 2024 Sep 9. Diabetologia. 2024. PMID: 39245780 Free PMC article.
Neprilysin inhibition improves intravenous but not oral glucose-mediated insulin secretion via GLP-1R signaling in mice with β-cell dysfunction.
Esser N, Mongovin SM, Parilla J, Barrow BM, Mundinger TO, Fountaine BS, Larmore MJ, Castillo JJ, Akter R, Hull RL, Zraika S. Esser N, et al. Among authors: fountaine bs. Am J Physiol Endocrinol Metab. 2022 Mar 1;322(3):E307-E318. doi: 10.1152/ajpendo.00234.2021. Epub 2022 Feb 7. Am J Physiol Endocrinol Metab. 2022. PMID: 35128957 Free PMC article.