Templin AT - Search Results

1

The islet tissue plasminogen activator/plasmin system is upregulated with human islet amyloid polypeptide aggregation and protects beta cells from aggregation-induced toxicity.

Esser N, Hogan MF, Templin AT, Akter R, Fountaine BS, Castillo JJ, El-Osta A, Manathunga L, Zhyvoloup A, Raleigh DP, Zraika S, Hull RL, Kahn SE. Esser N, et al. Among authors: templin at. Diabetologia. 2024 Sep;67(9):1897-1911. doi: 10.1007/s00125-024-06161-0. Epub 2024 Sep 9. Diabetologia. 2024. PMID: 39245780 Free PMC article.

2

Matrix Metalloproteinase-9 Protects Islets from Amyloid-induced Toxicity.

Meier DT, Tu LH, Zraika S, Hogan MF, Templin AT, Hull RL, Raleigh DP, Kahn SE. Meier DT, et al. Among authors: templin at. J Biol Chem. 2015 Dec 18;290(51):30475-85. doi: 10.1074/jbc.M115.676692. Epub 2015 Oct 19. J Biol Chem. 2015. PMID: 26483547 Free PMC article.

3

The S20G substitution in hIAPP is more amyloidogenic and cytotoxic than wild-type hIAPP in mouse islets.

Meier DT, Entrup L, Templin AT, Hogan MF, Mellati M, Zraika S, Hull RL, Kahn SE. Meier DT, et al. Among authors: templin at. Diabetologia. 2016 Oct;59(10):2166-71. doi: 10.1007/s00125-016-4045-x. Epub 2016 Sep 1. Diabetologia. 2016. PMID: 27393137 Free PMC article.

4

Use of the PET ligand florbetapir for in vivo imaging of pancreatic islet amyloid deposits in hIAPP transgenic mice.

Templin AT, Meier DT, Willard JR, Wolden-Hanson T, Conway K, Lin YG, Gillespie PJ, Bokvist KB, Attardo G, Kahn SE, Scheuner D, Hull RL. Templin AT, et al. Diabetologia. 2018 Oct;61(10):2215-2224. doi: 10.1007/s00125-018-4695-y. Epub 2018 Jul 25. Diabetologia. 2018. PMID: 30046852 Free PMC article.

5

Low concentration IL-1β promotes islet amyloid formation by increasing hIAPP release from humanised mouse islets in vitro.

Templin AT, Mellati M, Meier DT, Esser N, Hogan MF, Castillo JJ, Akter R, Raleigh DP, Zraika S, Hull RL, Kahn SE. Templin AT, et al. Diabetologia. 2020 Nov;63(11):2385-2395. doi: 10.1007/s00125-020-05232-2. Epub 2020 Jul 29. Diabetologia. 2020. PMID: 32728889 Free PMC article.

6

Islet amyloid polypeptide aggregation exerts cytotoxic and proinflammatory effects on the islet vasculature in mice.

Castillo JJ, Aplin AC, Hackney DJ, Hogan MF, Esser N, Templin AT, Akter R, Kahn SE, Raleigh DP, Zraika S, Hull RL. Castillo JJ, et al. Among authors: templin at. Diabetologia. 2022 Oct;65(10):1687-1700. doi: 10.1007/s00125-022-05756-9. Epub 2022 Jul 25. Diabetologia. 2022. PMID: 35871651 Free PMC article.

7

Inhibition of Insulin-Degrading Enzyme Does Not Increase Islet Amyloid Deposition in Vitro.

Hogan MF, Meier DT, Zraika S, Templin AT, Mellati M, Hull RL, Leissring MA, Kahn SE. Hogan MF, et al. Among authors: templin at. Endocrinology. 2016 Sep;157(9):3462-8. doi: 10.1210/en.2016-1410. Epub 2016 Jul 12. Endocrinology. 2016. PMID: 27404391 Free PMC article.

8

Apoptosis Repressor With Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation.

Templin AT, Samarasekera T, Meier DT, Hogan MF, Mellati M, Crow MT, Kitsis RN, Zraika S, Hull RL, Kahn SE. Templin AT, et al. Diabetes. 2017 Oct;66(10):2636-2645. doi: 10.2337/db16-1352. Epub 2017 Jul 20. Diabetes. 2017. PMID: 28729244 Free PMC article.

9

RNA-seq-based identification of Star upregulation by islet amyloid formation.

Hogan MF, Ziemann M, K N H, Rodriguez H, Kaspi A, Esser N, Templin AT, El-Osta A, Kahn SE. Hogan MF, et al. Among authors: templin at. Protein Eng Des Sel. 2019 Dec 13;32(2):67-76. doi: 10.1093/protein/gzz022. Protein Eng Des Sel. 2019. PMID: 31504890 Free PMC article.

10

Loss of perlecan heparan sulfate glycosaminoglycans lowers body weight and decreases islet amyloid deposition in human islet amyloid polypeptide transgenic mice.

Templin AT, Mellati M, Soininen R, Hogan MF, Esser N, Castillo JJ, Zraika S, Kahn SE, Hull RL. Templin AT, et al. Protein Eng Des Sel. 2019 Dec 13;32(2):95-102. doi: 10.1093/protein/gzz041. Protein Eng Des Sel. 2019. PMID: 31769491 Free PMC article.

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