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The islet tissue plasminogen activator/plasmin system is upregulated with human islet amyloid polypeptide aggregation and protects beta cells from aggregation-induced toxicity.
Esser N, Hogan MF, Templin AT, Akter R, Fountaine BS, Castillo JJ, El-Osta A, Manathunga L, Zhyvoloup A, Raleigh DP, Zraika S, Hull RL, Kahn SE. Esser N, et al. Among authors: zraika s. Diabetologia. 2024 Sep;67(9):1897-1911. doi: 10.1007/s00125-024-06161-0. Epub 2024 Sep 9. Diabetologia. 2024. PMID: 39245780 Free PMC article.
Matrix Metalloproteinase-9 Protects Islets from Amyloid-induced Toxicity.
Meier DT, Tu LH, Zraika S, Hogan MF, Templin AT, Hull RL, Raleigh DP, Kahn SE. Meier DT, et al. Among authors: zraika s. J Biol Chem. 2015 Dec 18;290(51):30475-85. doi: 10.1074/jbc.M115.676692. Epub 2015 Oct 19. J Biol Chem. 2015. PMID: 26483547 Free PMC article.
65 results