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ALDH1A3 is the switch that determines the balance of ALDH+ and CD24-CD44+ cancer stem cells, EMT-MET, and glucose metabolism in breast cancer.
Fernando W, Cruickshank BM, Arun RP, MacLean MR, Cahill HF, Morales-Quintanilla F, Dean CA, Wasson MD, Dahn ML, Coyle KM, Walker OL, Power Coombs MR, Marcato P. Fernando W, et al. Among authors: dean ca. Oncogene. 2024 Oct;43(43):3151-3169. doi: 10.1038/s41388-024-03156-4. Epub 2024 Sep 9. Oncogene. 2024. PMID: 39251846 Free PMC article.
Core needle biopsy of breast cancer tumors increases distant metastases in a mouse model.
Mathenge EG, Dean CA, Clements D, Vaghar-Kashani A, Photopoulos S, Coyle KM, Giacomantonio M, Malueth B, Nunokawa A, Jordan J, Lewis JD, Gujar SA, Marcato P, Lee PW, Giacomantonio CA. Mathenge EG, et al. Among authors: dean ca. Neoplasia. 2014 Nov 20;16(11):950-60. doi: 10.1016/j.neo.2014.09.004. eCollection 2014 Nov. Neoplasia. 2014. PMID: 25425969 Free PMC article.
The NAD(+) salvage pathway modulates cancer cell viability via p73.
Sharif T, Ahn DG, Liu RZ, Pringle E, Martell E, Dai C, Nunokawa A, Kwak M, Clements D, Murphy JP, Dean C, Marcato P, McCormick C, Godbout R, Gujar SA, Lee PW. Sharif T, et al. Cell Death Differ. 2016 Apr;23(4):669-80. doi: 10.1038/cdd.2015.134. Epub 2015 Nov 20. Cell Death Differ. 2016. PMID: 26586573 Free PMC article.
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