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Page 1
The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC.
Richard J, Grunst MW, Niu L, Díaz-Salinas MA, Tolbert WD, Marchitto L, Zhou F, Bourassa C, Yang D, Chiu TJ, Chen HC, Benlarbi M; Guillaume-Beaudoin-Buissières; Gottumukkala S, Li W, Dionne K, Bélanger É, Chatterjee D, Medjahed H, Hendrickson WA, Sodroski J, Lang ZC, Morton AJ, Huang RK, Matthies D, Smith AB 3rd, Mothes W, Munro JB, Pazgier M, Finzi A. Richard J, et al. Among authors: tolbert wd. bioRxiv [Preprint]. 2024 Aug 27:2024.08.27.609961. doi: 10.1101/2024.08.27.609961. bioRxiv. 2024. PMID: 39253431 Free PMC article. Preprint.
The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity.
Marchitto L, Richard J, Prévost J, Tauzin A, Yang D, Chiu T, Chen HC, Díaz-Salinas MA, Nayrac M, Benlarbi M, Beaudoin-Bussières G, Anand SP, Dionne K, Bélanger É, Chatterjee D, Medjahed H, Bourassa C, Tolbert WD, Hahn BH, Munro JB, Pazgier M, Smith AB 3rd, Finzi A. Marchitto L, et al. Among authors: tolbert wd. bioRxiv [Preprint]. 2024 Jun 7:2024.06.07.597978. doi: 10.1101/2024.06.07.597978. bioRxiv. 2024. Update in: J Virol. 2024 Oct 22;98(10):e0101624. doi: 10.1128/jvi.01016-24 PMID: 38895270 Free PMC article. Updated. Preprint.
Piperidine CD4-mimetic compounds expose vulnerable Env epitopes sensitizing HIV-1-infected cells to ADCC.
Ding S, Tolbert WD, Zhu H, Lee D, Higgins T, Zhao X, Nguyen D, Sherburn R, Richard J, Lepage GG, Medjahed H, Mohammadi M, Abrams C, Pazgier M, Smith AB 3rd, Finzi A. Ding S, et al. Among authors: tolbert wd. bioRxiv [Preprint]. 2023 Mar 24:2023.03.23.533923. doi: 10.1101/2023.03.23.533923. bioRxiv. 2023. Update in: Viruses. 2023 May 17;15(5):1185. doi: 10.3390/v15051185 PMID: 36993184 Free PMC article. Updated. Preprint.
Structure-function Analyses Reveal Key Molecular Determinants of HIV-1 CRF01_AE Resistance to the Entry Inhibitor Temsavir.
Prévost J, Chen Y, Zhou F, Tolbert WD, Gasser R, Medjahed H, Gottumukkala S, Hessell AJ, Rao VB, Pozharski E, Huang RK, Matthies D, Finzi A, Pazgier M. Prévost J, et al. Among authors: tolbert wd. bioRxiv [Preprint]. 2023 Apr 17:2023.04.17.537181. doi: 10.1101/2023.04.17.537181. bioRxiv. 2023. Update in: Nat Commun. 2023 Oct 23;14(1):6710. doi: 10.1038/s41467-023-42500-2 PMID: 37131729 Free PMC article. Updated. Preprint.
Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in presence of CD4-mimetics.
Tauzin A, Marchitto L, Bélanger É, Benlarbi M, Beaudoin-Bussières G, Prévost J, Yang D, Chiu TJ, Chen HC, Bourassa C, Medjahed H, Korzeniowski MK, Gottumukkala S, Tolbert WD, Richard J, Smith AB 3rd, Pazgier M, Finzi A. Tauzin A, et al. Among authors: tolbert wd. medRxiv [Preprint]. 2024 Jun 4:2024.06.02.24308281. doi: 10.1101/2024.06.02.24308281. medRxiv. 2024. Update in: J Virol. 2024 Oct 22;98(10):e0096024. doi: 10.1128/jvi.00960-24 PMID: 38883797 Free PMC article. Updated. Preprint.
The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity.
Marchitto L, Richard J, Prévost J, Tauzin A, Yang D, Chiu T-J, Chen H-C, Díaz-Salinas MA, Nayrac M, Benlarbi M, Beaudoin-Bussières G, Anand SP, Dionne K, Bélanger É, Chatterjee D, Medjahed H, Bourassa C, Tolbert WD, Hahn BH, Munro JB, Pazgier M, Smith AB 3rd, Finzi A. Marchitto L, et al. Among authors: tolbert wd. J Virol. 2024 Oct 22;98(10):e0101624. doi: 10.1128/jvi.01016-24. Epub 2024 Sep 9. J Virol. 2024. PMID: 39248460
Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in the presence of CD4-mimetics.
Tauzin A, Marchitto L, Bélanger É, Benlarbi M, Beaudoin-Bussières G, Prévost J, Yang D, Chiu T-J, Chen H-C, Bourassa C, Medjahed H, Korzeniowski MK, Gottumukkala S, Tolbert WD, Richard J, Smith AB 3rd, Pazgier M, Finzi A. Tauzin A, et al. Among authors: tolbert wd. J Virol. 2024 Oct 22;98(10):e0096024. doi: 10.1128/jvi.00960-24. Epub 2024 Sep 4. J Virol. 2024. PMID: 39230306
Structural Basis and Mode of Action for Two Broadly Neutralizing Antibodies Against SARS-CoV-2 Emerging Variants of Concern.
Li W, Chen Y, Prévost J, Ullah I, Lu M, Gong SY, Tauzin A, Gasser R, Vézina D, Anand SP, Goyette G, Chaterjee D, Ding S, Tolbert WD, Grunst MW, Bo Y, Zhang S, Richard J, Zhou F, Huang RK, Esser L, Zeher A, Côté M, Kumar P, Sodroski J, Xia D, Uchil PD, Pazgier M, Finzi A, Mothes W. Li W, et al. Among authors: tolbert wd. bioRxiv [Preprint]. 2021 Aug 3:2021.08.02.454546. doi: 10.1101/2021.08.02.454546. bioRxiv. 2021. Update in: Cell Rep. 2022 Jan 11;38(2):110210. doi: 10.1016/j.celrep.2021.110210 PMID: 34373853 Free PMC article. Updated. Preprint.
Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities.
Chen Y, Sun L, Ullah I, Beaudoin-Bussières G, Anand SP, Hederman AP, Tolbert WD, Sherburn R, Nguyen DN, Marchitto L, Ding S, Wu D, Luo Y, Gottumukkala S, Moran S, Kumar P, Piszczek G, Mothes W, Ackerman ME, Finzi A, Uchil PD, Gonzalez FJ, Pazgier M. Chen Y, et al. Among authors: tolbert wd. bioRxiv [Preprint]. 2021 Nov 24:2021.11.24.469776. doi: 10.1101/2021.11.24.469776. bioRxiv. 2021. Update in: Sci Adv. 2022 Jul 15;8(28):eabn4188. doi: 10.1126/sciadv.abn4188 PMID: 34845451 Free PMC article. Updated. Preprint.
77 results