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Challenges and recommendations for the translation of biomarkers of aging.
Biomarkers of Aging Consortium; Herzog CMS, Goeminne LJE, Poganik JR, Barzilai N, Belsky DW, Betts-LaCroix J, Chen BH, Chen M, Cohen AA, Cummings SR, Fedichev PO, Ferrucci L, Fleming A, Fortney K, Furman D, Gorbunova V, Higgins-Chen A, Hood L, Horvath S, Justice JN, Kiel DP, Kuchel GA, Lasky-Su J, LeBrasseur NK, Maier AB, Schilling B, Sebastiano V, Slagboom PE, Snyder MP, Verdin E, Widschwendter M, Zhavoronkov A, Moqri M, Gladyshev VN. Biomarkers of Aging Consortium, et al. Among authors: chen m, chen bh. Nat Aging. 2024 Oct;4(10):1372-1383. doi: 10.1038/s43587-024-00683-3. Epub 2024 Sep 16. Nat Aging. 2024. PMID: 39285015 Review.
Validation of biomarkers of aging.
Moqri M, Herzog C, Poganik JR, Ying K, Justice JN, Belsky DW, Higgins-Chen AT, Chen BH, Cohen AA, Fuellen G, Hägg S, Marioni RE, Widschwendter M, Fortney K, Fedichev PO, Zhavoronkov A, Barzilai N, Lasky-Su J, Kiel DP, Kennedy BK, Cummings S, Slagboom PE, Verdin E, Maier AB, Sebastiano V, Snyder MP, Gladyshev VN, Horvath S, Ferrucci L. Moqri M, et al. Among authors: chen bh. Nat Med. 2024 Feb;30(2):360-372. doi: 10.1038/s41591-023-02784-9. Epub 2024 Feb 14. Nat Med. 2024. PMID: 38355974 Free PMC article. Review.
An epigenetic biomarker of aging for lifespan and healthspan.
Levine ME, Lu AT, Quach A, Chen BH, Assimes TL, Bandinelli S, Hou L, Baccarelli AA, Stewart JD, Li Y, Whitsel EA, Wilson JG, Reiner AP, Aviv A, Lohman K, Liu Y, Ferrucci L, Horvath S. Levine ME, et al. Among authors: chen bh. Aging (Albany NY). 2018 Apr 18;10(4):573-591. doi: 10.18632/aging.101414. Aging (Albany NY). 2018. PMID: 29676998 Free PMC article.
Epigenetic clock analysis of diet, exercise, education, and lifestyle factors.
Quach A, Levine ME, Tanaka T, Lu AT, Chen BH, Ferrucci L, Ritz B, Bandinelli S, Neuhouser ML, Beasley JM, Snetselaar L, Wallace RB, Tsao PS, Absher D, Assimes TL, Stewart JD, Li Y, Hou L, Baccarelli AA, Whitsel EA, Horvath S. Quach A, et al. Among authors: chen bh. Aging (Albany NY). 2017 Feb 14;9(2):419-446. doi: 10.18632/aging.101168. Aging (Albany NY). 2017. PMID: 28198702 Free PMC article.
Blood DNA methylation sites predict death risk in a longitudinal study of 12, 300 individuals.
Colicino E, Marioni R, Ward-Caviness C, Gondalia R, Guan W, Chen B, Tsai PC, Huan T, Xu G, Golareh A, Schwartz J, Vokonas P, Just A, Starr JM, McRae AF, Wray NR, Visscher PM, Bressler J, Zhang W, Tanaka T, Moore AZ, Pilling LC, Zhang G, Stewart JD, Li Y, Hou L, Castillo-Fernandez J, Spector T, Kiel DP, Murabito JM, Liu C, Mendelson M, Assimes T, Absher D, Tsaho PS, Lu AT, Ferrucci L, Wilson R, Waldenberger M, Prokisch H, Bandinelli S, Bell JT, Levy D, Deary IJ, Horvath S, Pankow J, Peters A, Whitsel EA, Baccarelli A. Colicino E, et al. Aging (Albany NY). 2020 Jul 22;12(14):14092-14124. doi: 10.18632/aging.103408. Epub 2020 Jul 22. Aging (Albany NY). 2020. PMID: 32697766 Free PMC article.
DNA methylation-based measures of biological age: meta-analysis predicting time to death.
Chen BH, Marioni RE, Colicino E, Peters MJ, Ward-Caviness CK, Tsai PC, Roetker NS, Just AC, Demerath EW, Guan W, Bressler J, Fornage M, Studenski S, Vandiver AR, Moore AZ, Tanaka T, Kiel DP, Liang L, Vokonas P, Schwartz J, Lunetta KL, Murabito JM, Bandinelli S, Hernandez DG, Melzer D, Nalls M, Pilling LC, Price TR, Singleton AB, Gieger C, Holle R, Kretschmer A, Kronenberg F, Kunze S, Linseisen J, Meisinger C, Rathmann W, Waldenberger M, Visscher PM, Shah S, Wray NR, McRae AF, Franco OH, Hofman A, Uitterlinden AG, Absher D, Assimes T, Levine ME, Lu AT, Tsao PS, Hou L, Manson JE, Carty CL, LaCroix AZ, Reiner AP, Spector TD, Feinberg AP, Levy D, Baccarelli A, van Meurs J, Bell JT, Peters A, Deary IJ, Pankow JS, Ferrucci L, Horvath S. Chen BH, et al. Aging (Albany NY). 2016 Sep 28;8(9):1844-1865. doi: 10.18632/aging.101020. Aging (Albany NY). 2016. PMID: 27690265 Free PMC article.
GWAS of epigenetic aging rates in blood reveals a critical role for TERT.
Lu AT, Xue L, Salfati EL, Chen BH, Ferrucci L, Levy D, Joehanes R, Murabito JM, Kiel DP, Tsai PC, Yet I, Bell JT, Mangino M, Tanaka T, McRae AF, Marioni RE, Visscher PM, Wray NR, Deary IJ, Levine ME, Quach A, Assimes T, Tsao PS, Absher D, Stewart JD, Li Y, Reiner AP, Hou L, Baccarelli AA, Whitsel EA, Aviv A, Cardona A, Day FR, Wareham NJ, Perry JRB, Ong KK, Raj K, Lunetta KL, Horvath S. Lu AT, et al. Among authors: chen bh. Nat Commun. 2018 Jan 26;9(1):387. doi: 10.1038/s41467-017-02697-5. Nat Commun. 2018. PMID: 29374233 Free PMC article.
Predicting physiological aging rates from a range of quantitative traits using machine learning.
Sun ED, Qian Y, Oppong R, Butler TJ, Zhao J, Chen BH, Tanaka T, Kang J, Sidore C, Cucca F, Bandinelli S, Abecasis GR, Gorospe M, Ferrucci L, Schlessinger D, Goldberg I, Ding J. Sun ED, et al. Among authors: chen bh. Aging (Albany NY). 2021 Oct 29;13(20):23471-23516. doi: 10.18632/aging.203660. Epub 2021 Oct 29. Aging (Albany NY). 2021. PMID: 34718232 Free PMC article.
917 results