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HLA A*24:02-restricted T cell receptors cross-recognize bacterial and preproinsulin peptides in type 1 diabetes.
Dolton G, Bulek A, Wall A, Thomas H, Hopkins JR, Rius C, Galloway SA, Whalley T, Tan LR, Morin T, Omidvar N, Fuller A, Topley K, Hasan MS, Jain S, D'Souza N, Hodges-Hoyland T; TIRID Consortium; Spiller OB, Kronenberg-Versteeg D, Szomolay B, van den Berg HA, Jones LC, Peakman M, Cole DK, Rizkallah PJ, Sewell AK. Dolton G, et al. Among authors: fuller a. J Clin Invest. 2024 Sep 17;134(18):e164535. doi: 10.1172/JCI164535. J Clin Invest. 2024. PMID: 39286976 Free PMC article.
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.
Cole DK, Bulek AM, Dolton G, Schauenberg AJ, Szomolay B, Rittase W, Trimby A, Jothikumar P, Fuller A, Skowera A, Rossjohn J, Zhu C, Miles JJ, Peakman M, Wooldridge L, Rizkallah PJ, Sewell AK. Cole DK, et al. Among authors: fuller a. J Clin Invest. 2016 Jun 1;126(6):2191-204. doi: 10.1172/JCI85679. Epub 2016 May 16. J Clin Invest. 2016. PMID: 27183389 Free PMC article.
GPU-Accelerated Discovery of Pathogen-Derived Molecular Mimics of a T-Cell Insulin Epitope.
Whalley T, Dolton G, Brown PE, Wall A, Wooldridge L, van den Berg H, Fuller A, Hopkins JR, Crowther MD, Attaf M, Knight RR, Cole DK, Peakman M, Sewell AK, Szomolay B. Whalley T, et al. Among authors: fuller a. Front Immunol. 2020 Feb 28;11:296. doi: 10.3389/fimmu.2020.00296. eCollection 2020. Front Immunol. 2020. PMID: 32184781 Free PMC article.
Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy.
Dolton G, Rius C, Wall A, Szomolay B, Bianchi V, Galloway SAE, Hasan MS, Morin T, Caillaud ME, Thomas HL, Theaker S, Tan LR, Fuller A, Topley K, Legut M, Attaf M, Hopkins JR, Behiry E, Zabkiewicz J, Alvares C, Lloyd A, Rogers A, Henley P, Fegan C, Ottmann O, Man S, Crowther MD, Donia M, Svane IM, Cole DK, Brown PE, Rizkallah P, Sewell AK. Dolton G, et al. Among authors: fuller a. Cell. 2023 Aug 3;186(16):3333-3349.e27. doi: 10.1016/j.cell.2023.06.020. Epub 2023 Jul 24. Cell. 2023. PMID: 37490916 Free article.
Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.
Bulek AM, Cole DK, Skowera A, Dolton G, Gras S, Madura F, Fuller A, Miles JJ, Gostick E, Price DA, Drijfhout JW, Knight RR, Huang GC, Lissin N, Molloy PE, Wooldridge L, Jakobsen BK, Rossjohn J, Peakman M, Rizkallah PJ, Sewell AK. Bulek AM, et al. Among authors: fuller a. Nat Immunol. 2012 Jan 15;13(3):283-9. doi: 10.1038/ni.2206. Nat Immunol. 2012. PMID: 22245737 Free PMC article.
TCR/pMHC Optimized Protein crystallization Screen.
Bulek AM, Madura F, Fuller A, Holland CJ, Schauenburg AJ, Sewell AK, Rizkallah PJ, Cole DK. Bulek AM, et al. Among authors: fuller a. J Immunol Methods. 2012 Aug 31;382(1-2):203-10. doi: 10.1016/j.jim.2012.06.007. Epub 2012 Jun 15. J Immunol Methods. 2012. PMID: 22705983 Free PMC article.
T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting.
Ekeruche-Makinde J, Clement M, Cole DK, Edwards ES, Ladell K, Miles JJ, Matthews KK, Fuller A, Lloyd KA, Madura F, Dolton GM, Pentier J, Lissina A, Gostick E, Baxter TK, Baker BM, Rizkallah PJ, Price DA, Wooldridge L, Sewell AK. Ekeruche-Makinde J, et al. Among authors: fuller a. J Biol Chem. 2012 Oct 26;287(44):37269-81. doi: 10.1074/jbc.M112.386409. Epub 2012 Sep 5. J Biol Chem. 2012. PMID: 22952231 Free PMC article.
989 results