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Validation of a whole slide image management system for metabolic-associated steatohepatitis for clinical trials.
Pulaski H, Mehta SS, Manigat LC, Kaufman S, Hou H, Nalbantoglu I, Zhang X, Curl E, Taliano R, Kim TH, Torbenson M, Glickman JN, Resnick MB, Patel N, Taylor CE, Bedossa P, Montalto MC, Beck AH, Wack KE. Pulaski H, et al. Among authors: beck ah. J Pathol Clin Res. 2024 Sep;10(5):e12395. doi: 10.1002/2056-4538.12395. J Pathol Clin Res. 2024. PMID: 39294925 Free PMC article.
A Machine Learning Approach Enables Quantitative Measurement of Liver Histology and Disease Monitoring in NASH.
Taylor-Weiner A, Pokkalla H, Han L, Jia C, Huss R, Chung C, Elliott H, Glass B, Pethia K, Carrasco-Zevallos O, Shukla C, Khettry U, Najarian R, Taliano R, Subramanian GM, Myers RP, Wapinski I, Khosla A, Resnick M, Montalto MC, Anstee QM, Wong VW, Trauner M, Lawitz EJ, Harrison SA, Okanoue T, Romero-Gomez M, Goodman Z, Loomba R, Beck AH, Younossi ZM. Taylor-Weiner A, et al. Among authors: beck ah. Hepatology. 2021 Jul;74(1):133-147. doi: 10.1002/hep.31750. Epub 2021 Jun 24. Hepatology. 2021. PMID: 33570776 Free PMC article.
Human-interpretable image features derived from densely mapped cancer pathology slides predict diverse molecular phenotypes.
Diao JA, Wang JK, Chui WF, Mountain V, Gullapally SC, Srinivasan R, Mitchell RN, Glass B, Hoffman S, Rao SK, Maheshwari C, Lahiri A, Prakash A, McLoughlin R, Kerner JK, Resnick MB, Montalto MC, Khosla A, Wapinski IN, Beck AH, Elliott HL, Taylor-Weiner A. Diao JA, et al. Among authors: beck ah. Nat Commun. 2021 Mar 12;12(1):1613. doi: 10.1038/s41467-021-21896-9. Nat Commun. 2021. PMID: 33712588 Free PMC article.
A Machine Learning Approach to Liver Histological Evaluation Predicts Clinically Significant Portal Hypertension in NASH Cirrhosis.
Bosch J, Chung C, Carrasco-Zevallos OM, Harrison SA, Abdelmalek MF, Shiffman ML, Rockey DC, Shanis Z, Juyal D, Pokkalla H, Le QH, Resnick M, Montalto M, Beck AH, Wapinski I, Han L, Jia C, Goodman Z, Afdhal N, Myers RP, Sanyal AJ. Bosch J, et al. Among authors: beck ah. Hepatology. 2021 Dec;74(6):3146-3160. doi: 10.1002/hep.32087. Hepatology. 2021. PMID: 34333790 Free article.
Association of artificial intelligence-powered and manual quantification of programmed death-ligand 1 (PD-L1) expression with outcomes in patients treated with nivolumab ± ipilimumab.
Baxi V, Lee G, Duan C, Pandya D, Cohen DN, Edwards R, Chang H, Li J, Elliott H, Pokkalla H, Glass B, Agrawal N, Lahiri A, Wang D, Khosla A, Wapinski I, Beck A, Montalto M. Baxi V, et al. Mod Pathol. 2022 Nov;35(11):1529-1539. doi: 10.1038/s41379-022-01119-2. Epub 2022 Jul 15. Mod Pathol. 2022. PMID: 35840720 Free PMC article.
Integration of deep learning-based histopathology and transcriptomics reveals key genes associated with fibrogenesis in patients with advanced NASH.
Conway J, Pouryahya M, Gindin Y, Pan DZ, Carrasco-Zevallos OM, Mountain V, Subramanian GM, Montalto MC, Resnick M, Beck AH, Huss RS, Myers RP, Taylor-Weiner A, Wapinski I, Chung C. Conway J, et al. Among authors: beck ah. Cell Rep Med. 2023 Apr 18;4(4):101016. doi: 10.1016/j.xcrm.2023.101016. Cell Rep Med. 2023. PMID: 37075704 Free PMC article.
AI-based histologic scoring enables automated and reproducible assessment of enrollment criteria and endpoints in NASH clinical trials.
Iyer JS, Pokkalla H, Biddle-Snead C, Carrasco-Zevallos O, Lin M, Shanis Z, Le Q, Juyal D, Pouryahya M, Pedawi A, Hoffman S, Elliott H, Leidal K, Myers RP, Chung C, Billin AN, Watkins TR, Resnick M, Wack K, Glickman J, Burt AD, Loomba R, Sanyal AJ, Montalto MC, Beck AH, Taylor-Weiner A, Wapinski I. Iyer JS, et al. Among authors: beck ah. medRxiv [Preprint]. 2023 Apr 25:2023.04.20.23288534. doi: 10.1101/2023.04.20.23288534. medRxiv. 2023. PMID: 37162870 Free PMC article. Preprint.
AI-based automation of enrollment criteria and endpoint assessment in clinical trials in liver diseases.
Iyer JS, Juyal D, Le Q, Shanis Z, Pokkalla H, Pouryahya M, Pedawi A, Stanford-Moore SA, Biddle-Snead C, Carrasco-Zevallos O, Lin M, Egger R, Hoffman S, Elliott H, Leidal K, Myers RP, Chung C, Billin AN, Watkins TR, Patterson SD, Resnick M, Wack K, Glickman J, Burt AD, Loomba R, Sanyal AJ, Glass B, Montalto MC, Taylor-Weiner A, Wapinski I, Beck AH. Iyer JS, et al. Among authors: beck ah. Nat Med. 2024 Oct;30(10):2914-2923. doi: 10.1038/s41591-024-03172-7. Epub 2024 Aug 7. Nat Med. 2024. PMID: 39112795 Free PMC article.
154 results