Chan TH - Search Results

1

Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety.

Surur AS, Chan CF, Bartz FM, Wong ILK, Nguyen VTD, Schulig L, Link A, Chan TH, Chow LMC, Bednarski PJ. Surur AS, et al. Among authors: chan th. RSC Med Chem. 2024 Aug 30;15(11):3837-52. doi: 10.1039/d4md00426d. Online ahead of print. RSC Med Chem. 2024. PMID: 39297060 Free article.

2

Identification of Binding Sites in the Nucleotide-Binding Domain of P-Glycoprotein for a Potent and Nontoxic Modulator, the Amine-Containing Monomeric Flavonoid FM04.

Liu Z, Wong ILK, Sang J, Liu F, Yan CSW, Kan JWY, Chan TH, Chow LMC. Liu Z, et al. Among authors: chan th. J Med Chem. 2023 May 11;66(9):6160-6183. doi: 10.1021/acs.jmedchem.2c02005. Epub 2023 Apr 25. J Med Chem. 2023. PMID: 37098275

3

Discovery of a Flavonoid FM04 as a Potent Inhibitor to Reverse P-Glycoprotein-Mediated Drug Resistance in Xenografts and Improve Oral Bioavailability of Paclitaxel.

Kan JWY, Yan CSW, Wong ILK, Su X, Liu Z, Chan TH, Chow LMC. Kan JWY, et al. Among authors: chan th. Int J Mol Sci. 2022 Dec 4;23(23):15299. doi: 10.3390/ijms232315299. Int J Mol Sci. 2022. PMID: 36499627 Free PMC article.

4

Characterization of a Potent, Selective, and Safe Inhibitor, Ac15(Az8)₂, in Reversing Multidrug Resistance Mediated by Breast Cancer Resistance Protein (BCRP/ABCG2).

Chong TC, Wong ILK, Cui J, Law MC, Zhu X, Hu X, Kan JWY, Yan CSW, Chan TH, Chow LMC. Chong TC, et al. Among authors: chan th. Int J Mol Sci. 2022 Oct 31;23(21):13261. doi: 10.3390/ijms232113261. Int J Mol Sci. 2022. PMID: 36362047 Free PMC article.

5

In Vivo Reversal of P-Glycoprotein-Mediated Drug Resistance in a Breast Cancer Xenograft and in Leukemia Models Using a Novel, Potent, and Nontoxic Epicatechin EC31.

Sun W, Wong ILK, Law HK, Su X, Chan TCF, Sun G, Yang X, Wang X, Chan TH, Wan S, Chow LMC. Sun W, et al. Among authors: chan th, chan tcf. Int J Mol Sci. 2023 Feb 22;24(5):4377. doi: 10.3390/ijms24054377. Int J Mol Sci. 2023. PMID: 36901808 Free PMC article.

6

Synthesis and structure-activity relationships of 2-pyrazinylcarboxamidobenzoates and beta-ionylideneacetamidobenzoates with retinoidal activity.

Jones P, Villeneuve GB, Fei C, DeMarte J, Haggarty AJ, Nwe KT, Martin DA, Lebuis AM, Finkelstein JM, Gour-Salin BJ, Chan TH, Leyland-Jones BR. Jones P, et al. Among authors: chan th. J Med Chem. 1998 Jul 30;41(16):3062-77. doi: 10.1021/jm9801354. J Med Chem. 1998. PMID: 9685246

7

Indium-mediated organometallic reactions in aqueous media. Stereoselectivity in the crotylation of sulfonimines bearing a proximal chelating group.

Lu W, Chan TH. Lu W, et al. Among authors: chan th. J Org Chem. 2001 May 18;66(10):3467-73. doi: 10.1021/jo0018038. J Org Chem. 2001. PMID: 11348131

8

Organometallic reactions in aqueous media. Indium- and zinc-mediated allylation of sulfonimines.

Lu W, Chan TH. Lu W, et al. Among authors: chan th. J Org Chem. 2000 Dec 15;65(25):8589-94. doi: 10.1021/jo0009898. J Org Chem. 2000. PMID: 11112579

9

Regioselective Acylation of Hexopyranosides with Pivaloyl Chloride.

Jiang L, Chan TH. Jiang L, et al. Among authors: chan th. J Org Chem. 1998 Aug 21;63(17):6035-6038. doi: 10.1021/jo980294v. J Org Chem. 1998. PMID: 11672212 No abstract available.

10

Manganese-Mediated Carbon-Carbon Bond Formation in Aqueous Media: Chemoselective Allylation and Pinacol Coupling of Aryl Aldehydes.

Li CJ, Meng Y, Yi XH, Ma J, Chan TH. Li CJ, et al. Among authors: chan th. J Org Chem. 1998 Oct 16;63(21):7498-7504. doi: 10.1021/jo980535z. J Org Chem. 1998. PMID: 11672403

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