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Page 1
Improving the Assessment of Risk Factors Relevant to Potential Carcinogenicity of Gene Therapies: A Consensus Article.
Klapwijk JC, Del Rio Espinola A, Libertini S, Collin P, Fellows MD, Jobling S, Lynch AM, Martus H, Vickers C, Zeller A, Biasco L, Brugman MH, Bushmann FD, Cathomen T, Ertl HCJ, Gabriel R, Gao G, Jadlowsky JK, Kimber I, Lanz TA, Levine BL, Micklethwaite KP, Onodera M, Pizzurro DM, Reed S, Rothe M, Sabatino DE, Salk JJ, Schambach A, Themis M, Yuan J. Klapwijk JC, et al. Among authors: jadlowsky jk. Hum Gene Ther. 2024 Aug;35(15-16):527-542. doi: 10.1089/hum.2024.033. Hum Gene Ther. 2024. PMID: 39049734 Review.
Accelerating the development of genetically engineered cellular therapies: a framework for extrapolating data across related products.
Stewart MD, Kalos M, Coutinho V, Better M, Jazayeri J, Yohrling J, Jadlowsky J, Fuchs M, Gidwani S, Goessl C, Hanley PJ, Healy J, Liu W, McKelvey BA, Pearce L, Pilon-Thomas S, Andrews HS, Veldman M, Vong J, Weinbach SP, Allen JD. Stewart MD, et al. Cytotherapy. 2024 Jul;26(7):778-784. doi: 10.1016/j.jcyt.2024.03.009. Epub 2024 Mar 16. Cytotherapy. 2024. PMID: 38583170 Free article.
Identification of Core Techniques That Enhance Genome Editing of Human T Cells Expressing Synthetic Antigen Receptors.
Chang JF, Wellhausen N, Engel NW, Landmann JH, Hopkins CR, Salas-McKee J, Bear AS, Selli ME, Agarwal S, Jadlowsky JK, Linette GP, Gill S, June CH, Fraietta JA, Singh N. Chang JF, et al. Among authors: jadlowsky jk. Cancer Immunol Res. 2024 Sep 3;12(9):1136-1146. doi: 10.1158/2326-6066.CIR-24-0251. Cancer Immunol Res. 2024. PMID: 38869428 Review.
TET2 regulates early and late transitions in exhausted CD8+ T cell differentiation and limits CAR T cell function.
Dimitri AJ, Baxter AE, Chen GM, Hopkins CR, Rouin GT, Huang H, Kong W, Holliday CH, Wiebking V, Bartoszek R, Drury S, Dalton K, Koucky OM, Chen Z, Giles JR, Dils AT, Jung IY, O'Connor R, Collins S, Everett JK, Amses K, Sherrill-Mix S, Chandra A, Goldman N, Vahedi G, Jadlowsky JK, Young RM, Melenhorst JJ, Maude SL, Levine BL, Frey NV, Berger SL, Grupp SA, Porter DL, Herbst F, Porteus MH, Carty SA, Bushman FD, Weber EW, Wherry EJ, Jordan MS, Fraietta JA. Dimitri AJ, et al. Among authors: jadlowsky jk. Sci Adv. 2024 Nov 15;10(46):eadp9371. doi: 10.1126/sciadv.adp9371. Epub 2024 Nov 13. Sci Adv. 2024. PMID: 39536093 Free PMC article.
Regulatory Considerations for Genome-Edited T-cell Therapies.
Jadlowsky JK, Chang JF, Spencer DH, Warrington JM, Levine BL, June CH, Fraietta JA, Singh N. Jadlowsky JK, et al. Cancer Immunol Res. 2024 Sep 3;12(9):1132-1135. doi: 10.1158/2326-6066.CIR-24-0482. Cancer Immunol Res. 2024. PMID: 39018097 Review.
CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication.
Tebas P, Jadlowsky JK, Shaw PA, Tian L, Esparza E, Brennan AL, Kim S, Naing SY, Richardson MW, Vogel AN, Maldini CR, Kong H, Liu X, Lacey SF, Bauer AM, Mampe F, Richman LP, Lee G, Ando D, Levine BL, Porter DL, Zhao Y, Siegel DL, Bar KJ, June CH, Riley JL. Tebas P, et al. Among authors: jadlowsky jk. J Clin Invest. 2024 May 1;134(9):e181576. doi: 10.1172/JCI181576. J Clin Invest. 2024. PMID: 38690741 Free PMC article. No abstract available.
Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results.
Bagley SJ, Logun M, Fraietta JA, Wang X, Desai AS, Bagley LJ, Nabavizadeh A, Jarocha D, Martins R, Maloney E, Lledo L, Stein C, Marshall A, Leskowitz R, Jadlowsky JK, Christensen S, Oner BS, Plesa G, Brennan A, Gonzalez V, Chen F, Sun Y, Gladney W, Barrett D, Nasrallah MP, Hwang WT, Ming GL, Song H, Siegel DL, June CH, Hexner EO, Binder ZA, O'Rourke DM. Bagley SJ, et al. Among authors: jadlowsky jk. Nat Med. 2024 May;30(5):1320-1329. doi: 10.1038/s41591-024-02893-z. Epub 2024 Mar 13. Nat Med. 2024. PMID: 38480922 Clinical Trial.
Long-term stability of clinical-grade lentiviral vectors for cell therapy.
Jadlowsky JK, Leskowitz R, McKenna S, Karar J, Ma Y, Dai A, Plesa G, Chen F, Alexander K, Petrella J, Gong N, Hwang WT, Farrelly O, Barber-Rotenberg J, Christensen S, Gonzalez VE, Chew A, Fraietta JA, June CH. Jadlowsky JK, et al. Mol Ther Methods Clin Dev. 2024 Jan 10;32(1):101186. doi: 10.1016/j.omtm.2024.101186. eCollection 2024 Mar 14. Mol Ther Methods Clin Dev. 2024. PMID: 38282894 Free PMC article.
Tissue-resident memory CAR T cells with stem-like characteristics display enhanced efficacy against solid and liquid tumors.
Jung IY, Noguera-Ortega E, Bartoszek R, Collins SM, Williams E, Davis M, Jadlowsky JK, Plesa G, Siegel DL, Chew A, Levine BL, Berger SL, Moon EK, Albelda SM, Fraietta JA. Jung IY, et al. Among authors: jadlowsky jk. Cell Rep Med. 2023 Jun 20;4(6):101053. doi: 10.1016/j.xcrm.2023.101053. Epub 2023 May 23. Cell Rep Med. 2023. PMID: 37224816 Free PMC article.
23 results