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Two-dose priming immunization amplifies humoral immunity by synchronizing vaccine delivery with the germinal center response.
Bhagchandani SH, Yang L, Lam JH, Maiorino L, Ben-Akiva E, Rodrigues KA, Romanov A, Suh H, Aung A, Wu S, Wadhera A, Chakraborty AK, Irvine DJ. Bhagchandani SH, et al. Among authors: maiorino l. Sci Immunol. 2024 Sep 20;9(99):eadl3755. doi: 10.1126/sciimmunol.adl3755. Epub 2024 Sep 20. Sci Immunol. 2024. PMID: 39303017 Free PMC article.
Identification of Highly Cross-Reactive Mimotopes for a Public T Cell Response in Murine Melanoma.
Grace BE, Backlund CM, Morgan DM, Kang BH, Singh NK, Huisman BD, Rappazzo CG, Moynihan KD, Maiorino L, Dobson CS, Kyung T, Gordon KS, Holec PV, Mbah OCT, Garafola D, Wu S, Love JC, Wittrup KD, Irvine DJ, Birnbaum ME. Grace BE, et al. Among authors: maiorino l. Front Immunol. 2022 Jun 23;13:886683. doi: 10.3389/fimmu.2022.886683. eCollection 2022. Front Immunol. 2022. PMID: 35812387 Free PMC article.
Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity.
Hartwell BL, Melo MB, Xiao P, Lemnios AA, Li N, Chang JYH, Yu J, Gebre MS, Chang A, Maiorino L, Carter C, Moyer TJ, Dalvie NC, Rodriguez-Aponte SA, Rodrigues KA, Silva M, Suh H, Adams J, Fontenot J, Love JC, Barouch DH, Villinger F, Ruprecht RM, Irvine DJ. Hartwell BL, et al. Among authors: maiorino l. Sci Transl Med. 2022 Jul 20;14(654):eabn1413. doi: 10.1126/scitranslmed.abn1413. Epub 2022 Jul 20. Sci Transl Med. 2022. PMID: 35857825 Free PMC article.
Cell-penetrating peptides enhance peptide vaccine accumulation and persistence in lymph nodes to drive immunogenicity.
Backlund CM, Holden RL, Moynihan KD, Garafola D, Farquhar C, Mehta NK, Maiorino L, Pham S, Iorgulescu JB, Reardon DA, Wu CJ, Pentelute BL, Irvine DJ. Backlund CM, et al. Among authors: maiorino l. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2204078119. doi: 10.1073/pnas.2204078119. Epub 2022 Aug 1. Proc Natl Acad Sci U S A. 2022. PMID: 35914154 Free PMC article.
Low protease activity in B cell follicles promotes retention of intact antigens after immunization.
Aung A, Cui A, Maiorino L, Amini AP, Gregory JR, Bukenya M, Zhang Y, Lee H, Cottrell CA, Morgan DM, Silva M, Suh H, Kirkpatrick JD, Amlashi P, Remba T, Froehle LM, Xiao S, Abraham W, Adams J, Love JC, Huyett P, Kwon DS, Hacohen N, Schief WR, Bhatia SN, Irvine DJ. Aung A, et al. Among authors: maiorino l. Science. 2023 Jan 27;379(6630):eabn8934. doi: 10.1126/science.abn8934. Epub 2023 Jan 27. Science. 2023. PMID: 36701450 Free PMC article.
Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity.
Ma L, Hostetler A, Morgan DM, Maiorino L, Sulkaj I, Whittaker CA, Neeser A, Pires IS, Yousefpour P, Gregory J, Qureshi K, Dye J, Abraham W, Suh H, Li N, Love JC, Irvine DJ. Ma L, et al. Among authors: maiorino l. Cell. 2023 Jul 20;186(15):3148-3165.e20. doi: 10.1016/j.cell.2023.06.002. Epub 2023 Jul 5. Cell. 2023. PMID: 37413990 Free PMC article.
A combined adjuvant approach primes robust germinal center responses and humoral immunity in non-human primates.
Phung I, Rodrigues KA, Marina-Zárate E, Maiorino L, Pahar B, Lee WH, Melo M, Kaur A, Allers C, Fahlberg M, Grasperge BF, Dufour JP, Schiro F, Aye PP, Lopez PG, Torres JL, Ozorowski G, Eskandarzadeh S, Kubitz M, Georgeson E, Groschel B, Nedellec R, Bick M, Kaczmarek Michaels K, Gao H, Shen X, Carnathan DG, Silvestri G, Montefiori DC, Ward AB, Hangartner L, Veazey RS, Burton DR, Schief WR, Irvine DJ, Crotty S. Phung I, et al. Among authors: maiorino l. Nat Commun. 2023 Nov 4;14(1):7107. doi: 10.1038/s41467-023-42923-x. Nat Commun. 2023. PMID: 37925510 Free PMC article.
Two-dose "extended priming" immunization amplifies humoral immune responses by synchronizing vaccine delivery with the germinal center response.
Bhagchandani SH, Yang L, Maiorino L, Ben-Akiva E, Rodrigues KA, Romanov A, Suh H, Aung A, Wu S, Wadhera A, Chakraborty AK, Irvine DJ. Bhagchandani SH, et al. Among authors: maiorino l. bioRxiv [Preprint]. 2023 Nov 21:2023.11.20.563479. doi: 10.1101/2023.11.20.563479. bioRxiv. 2023. Update in: Sci Immunol. 2024 Sep 20;9(99):eadl3755. doi: 10.1126/sciimmunol.adl3755 PMID: 38045401 Free PMC article. Updated. Preprint.
Local delivery of cell surface-targeted immunocytokines programs systemic antitumor immunity.
Santollani L, Maiorino L, Zhang YJ, Palmeri JR, Stinson JA, Duhamel LR, Qureshi K, Suggs JR, Porth OT, Pinney W 3rd, Msari RA, Walsh AA, Wittrup KD, Irvine DJ. Santollani L, et al. Among authors: maiorino l. Nat Immunol. 2024 Oct;25(10):1820-1829. doi: 10.1038/s41590-024-01925-7. Epub 2024 Aug 7. Nat Immunol. 2024. PMID: 39112631 Free PMC article.
83 results