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2,437 results

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IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis.
Zhang P, Liu J, Lee A, Tsaur I, Ohira M, Duong V, Vo N, Watari K, Su H, Kim JY, Gu L, Zhu M, Shalapour S, Hosseini M, Bandyopadhyay G, Zeng S, Llorente C, Zhao HN, Lamichhane S, Mohan S, Dorrestein PC, Olefsky JM, Schnabl B, Soroosh P, Karin M. Zhang P, et al. Among authors: hosseini m. Cell Metab. 2024 Oct 1;36(10):2341-2354.e6. doi: 10.1016/j.cmet.2024.08.012. Epub 2024 Sep 23. Cell Metab. 2024. PMID: 39317186 Free article.
Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet.
Ganguly S, Muench GA, Shang L, Rosenthal SB, Rahman G, Wang R, Wang Y, Kwon HC, Diomino AM, Kisseleva T, Soorosh P, Hosseini M, Knight R, Schnabl B, Brenner DA, Dhar D. Ganguly S, et al. Among authors: hosseini m. Cell Mol Gastroenterol Hepatol. 2021;12(3):891-920. doi: 10.1016/j.jcmgh.2021.05.010. Epub 2021 May 29. Cell Mol Gastroenterol Hepatol. 2021. PMID: 34062281 Free PMC article.
Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice.
Baglieri J, Zhang C, Liang S, Liu X, Nishio T, Rosenthal SB, Dhar D, Su H, Cong M, Jia J, Hosseini M, Karin M, Kisseleva T, Brenner DA. Baglieri J, et al. Among authors: hosseini m. Am J Pathol. 2021 Sep;191(9):1564-1579. doi: 10.1016/j.ajpath.2021.05.019. Epub 2021 Jun 11. Am J Pathol. 2021. PMID: 34119473 Free PMC article.
CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease.
Duan Y, Chu H, Brandl K, Jiang L, Zeng S, Meshgin N, Papachristoforou E, Argemi J, Mendes BG, Wang Y, Su H, Sun W, Llorente C, Hendrikx T, Liu X, Hosseini M, Kisseleva T, Brenner DA, Bataller R, Ramachandran P, Karin M, Fu W, Schnabl B. Duan Y, et al. Among authors: hosseini m. Nat Commun. 2021 Dec 9;12(1):7172. doi: 10.1038/s41467-021-27385-3. Nat Commun. 2021. PMID: 34887405 Free PMC article.
Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD.
Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M, Mekeel K, Schnabl B, Loomba R, Karin M, Brenner DA, Kisseleva T. Carvalho-Gontijo R, et al. Among authors: hosseini m. Semin Liver Dis. 2022 Aug;42(3):233-249. doi: 10.1055/s-0042-1755316. Epub 2022 Aug 24. Semin Liver Dis. 2022. PMID: 36001995 Free PMC article. Review.
HIF-2α drives hepatic Kupffer cell death and proinflammatory recruited macrophage activation in nonalcoholic steatohepatitis.
Jeelani I, Moon JS, da Cunha FF, Nasamran CA, Jeon S, Zhang X, Bandyopadhyay GK, Dobaczewska K, Mikulski Z, Hosseini M, Liu X, Kisseleva T, Brenner DA, Singh S, Loomba R, Kim M, Lee YS. Jeelani I, et al. Among authors: hosseini m. Sci Transl Med. 2024 Sep 11;16(764):eadi0284. doi: 10.1126/scitranslmed.adi0284. Epub 2024 Sep 11. Sci Transl Med. 2024. PMID: 39259813
Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice.
Xu J, Ma HY, Liu X, Rosenthal S, Baglieri J, McCubbin R, Sun M, Koyama Y, Geoffroy CG, Saijo K, Shang L, Nishio T, Maricic I, Kreifeldt M, Kusumanchi P, Roberts A, Zheng B, Kumar V, Zengler K, Pizzo DP, Hosseini M, Contet C, Glass CK, Liangpunsakul S, Tsukamoto H, Gao B, Karin M, Brenner DA, Koob GF, Kisseleva T. Xu J, et al. Among authors: hosseini m. JCI Insight. 2020 Feb 13;5(3):e131277. doi: 10.1172/jci.insight.131277. JCI Insight. 2020. PMID: 32051339 Free PMC article.
Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes.
Bennett H, Troutman TD, Zhou E, Spann NJ, Link VM, Seidman JS, Nickl CK, Abe Y, Sakai M, Pasillas MP, Marlman JM, Guzman C, Hosseini M, Schnabl B, Glass CK. Bennett H, et al. Among authors: hosseini m. Nat Immunol. 2023 Nov;24(11):1825-1838. doi: 10.1038/s41590-023-01631-w. Epub 2023 Sep 21. Nat Immunol. 2023. PMID: 37735593 Free PMC article.
2,437 results