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802 results

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Page 1
Systematic characterization of therapeutic vulnerabilities in Multiple Myeloma with Amp1q reveals increased sensitivity to the combination of MCL1 and PI3K inhibitors.
Sklavenitis-Pistofidis R, Lightbody ED, Reidy M, Tsuji J, Aranha MP, Heilpern-Mallory D, Huynh D, Chong SJF, Hackett L, Haradhvala NJ, Wu T, Su NK, Berrios B, Alberge JB, Dutta A, Davids MS, Papaioannou M, Getz G, Ghobrial IM, Manier S. Sklavenitis-Pistofidis R, et al. Among authors: getz g. bioRxiv [Preprint]. 2023 Aug 3:2023.08.01.551480. doi: 10.1101/2023.08.01.551480. bioRxiv. 2023. PMID: 37577538 Free PMC article. Preprint.
Genomic profiling of mycosis fungoides identifies patients at high risk of disease progression.
Fléchon L, Arib I, Dutta AK, Hasan Bou Issa L, Sklavenitis-Pistofidis R, Tilmont R, Stewart C, Dubois R, Poulain S, Copin MC, Javed S, Nudel M, Cavalieri D, Escure G, Gower N, Chauvet P, Gazeau N, Saade C, Thiam MB, Ouelkite-Oumouchal A, Gaggero S, Cailliau É, Faiz S, Carpentier O, Duployez N, Idziorek T, Mortier L, Figeac M, Preudhomme C, Quesnel B, Mitra S, Morschhauser F, Getz G, Ghobrial IM, Manier S. Fléchon L, et al. Among authors: getz g. Blood Adv. 2024 Jun 25;8(12):3109-3119. doi: 10.1182/bloodadvances.2023012125. Blood Adv. 2024. PMID: 38513135 Free PMC article.
Inhibition of MICA and MICB shedding enhances memory-like NK-cell-mediated cytotoxicity against multiple myeloma.
Tahri S, Piccinelli S, Su NK, Lampe L, Dong H, Vergara Cadavid J, Boiarsky R, Papazian N, Lightbody ED, Cao A, Alberge JB, Ferrari de Andrade L, Rahmat M, Shen Y, Blanco Fernández L, Zabaleta A, Günther A, Getz G, Sonneveld P, Cupedo T, Wucherpfennig KW, Ghobrial IM, Romee R. Tahri S, et al. Among authors: getz g. Blood Adv. 2024 Oct 22;8(20):5365-5370. doi: 10.1182/bloodadvances.2023010869. Blood Adv. 2024. PMID: 39106432 Free PMC article. No abstract available.
Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas.
Campbell JD, Alexandrov A, Kim J, Wala J, Berger AH, Pedamallu CS, Shukla SA, Guo G, Brooks AN, Murray BA, Imielinski M, Hu X, Ling S, Akbani R, Rosenberg M, Cibulskis C, Ramachandran A, Collisson EA, Kwiatkowski DJ, Lawrence MS, Weinstein JN, Verhaak RG, Wu CJ, Hammerman PS, Cherniack AD, Getz G; Cancer Genome Atlas Research Network; Artyomov MN, Schreiber R, Govindan R, Meyerson M. Campbell JD, et al. Among authors: getz g. Nat Genet. 2016 Jun;48(6):607-16. doi: 10.1038/ng.3564. Epub 2016 May 9. Nat Genet. 2016. PMID: 27158780 Free PMC article.
Long-Term Follow-Up Defines the Population That Benefits from Early Interception in a High-Risk Smoldering Multiple Myeloma Clinical Trial Using the Combination of Ixazomib, Lenalidomide, and Dexamethasone.
Nadeem O, Aranha MP, Redd R, Timonian M, Magidson S, Lightbody ED, Alberge JB, Bertamini L, Dutta AK, El-Khoury H, Bustoros M, Laubach JP, Bianchi G, O'Donnell E, Wu T, Tsuji J, Anderson K, Getz G, Trippa L, Richardson PG, Sklavenitis-Pistofidis R, Ghobrial IM. Nadeem O, et al. Among authors: getz g. medRxiv [Preprint]. 2024 Apr 19:2024.04.19.24306082. doi: 10.1101/2024.04.19.24306082. medRxiv. 2024. PMID: 38699307 Free PMC article. Preprint.
Germline mutations and developmental mosaicism underlying EGFR-mutant lung cancer.
Burr R, Leshchiner I, Costantino CL, Blohmer M, Sundaresan T, Cha J, Seeger K, Guay S, Danysh BP, Gore I, Jacobs RA, Slowik K, Utro F, Rhrissorrakrai K, Levovitz C, Barth JL, Dubash T, Chirn B, Parida L, Sequist LV, Lennerz JK, Mino-Kenudson M, Maheswaran S, Naxerova K, Getz G, Haber DA. Burr R, et al. Among authors: getz g. medRxiv [Preprint]. 2023 Sep 29:2023.09.28.23296274. doi: 10.1101/2023.09.28.23296274. medRxiv. 2023. Update in: Nat Cancer. 2024 Oct 15. doi: 10.1038/s43018-024-00840-y PMID: 37808694 Free PMC article. Updated. Preprint.
Hypoxia is linked to acquired resistance to immune checkpoint inhibitors in lung cancer.
Robles-Oteíza C, Hastings K, Choi J, Sirois I, Ravi A, Expósito F, de Miguel F, Knight JR, López-Giráldez F, Choi H, Socci ND, Merghoub T, Awad M, Getz G, Gainor J, Hellmann MD, Caron É, Kaech SM, Politi K. Robles-Oteíza C, et al. Among authors: getz g. J Exp Med. 2025 Jan 6;222(1):e20231106. doi: 10.1084/jem.20231106. Epub 2024 Nov 25. J Exp Med. 2025. PMID: 39585348
Serum free light chains in a racially diverse population including African Americans and populations from South Africa.
Bertamini L, Alberge JB, Lee DJ, El-Khoury H, Kim S, Fleming G, Murphy CSM, Colchie J, Davis MI, Perry J, Lightbody ED, Allam S, Goqwana LN, Philip V, Smyth NA NA, Sakrikar D, Perkins MC, Harding S, Troske D, Getz G, Karlson EW, Munshi NC, Anderson KC, Trippa L, Marinac CR, Chen WC, Joffe M, Ghobrial IM. Bertamini L, et al. Among authors: getz g. Blood. 2024 Nov 21:blood.2024026078. doi: 10.1182/blood.2024026078. Online ahead of print. Blood. 2024. PMID: 39571144
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