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Unraveling the Protective Role of Oleocanthal and Its Oxidation Product, Oleocanthalic Acid, against Neuroinflammation.
Barbalace MC, Freschi M, Rinaldi I, Zallocco L, Malaguti M, Manera C, Ortore G, Zuccarini M, Ronci M, Cuffaro D, Macchia M, Hrelia S, Giusti L, Digiacomo M, Angeloni C. Barbalace MC, et al. Among authors: digiacomo m. Antioxidants (Basel). 2024 Sep 3;13(9):1074. doi: 10.3390/antiox13091074. Antioxidants (Basel). 2024. PMID: 39334733 Free PMC article.
Design, synthesis and preliminary evaluation of (18)F-labelled 1,8-naphthyridin- and quinolin-2-one-3-carboxamide derivatives for PET imaging of CB2 cannabinoid receptor.
Saccomanni G, Pascali G, Carlo SD, Panetta D, De Simone M, Bertini S, Burchielli S, Digiacomo M, Macchia M, Manera C, Salvadori PA. Saccomanni G, et al. Among authors: digiacomo m. Bioorg Med Chem Lett. 2015 Jun 15;25(12):2532-5. doi: 10.1016/j.bmcl.2015.04.055. Epub 2015 Apr 25. Bioorg Med Chem Lett. 2015. PMID: 25956416
Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor.
Bertini S, Chicca A, Gado F, Arena C, Nieri D, Digiacomo M, Saccomanni G, Zhao P, Abood ME, Macchia M, Gertsch J, Manera C. Bertini S, et al. Among authors: digiacomo m. Bioorg Med Chem. 2017 Dec 15;25(24):6427-6434. doi: 10.1016/j.bmc.2017.10.015. Epub 2017 Oct 16. Bioorg Med Chem. 2017. PMID: 29079014 Free PMC article.
Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief.
Gado F, Di Cesare Mannelli L, Lucarini E, Bertini S, Cappelli E, Digiacomo M, Stevenson LA, Macchia M, Tuccinardi T, Ghelardini C, Pertwee RG, Manera C. Gado F, et al. Among authors: digiacomo m. J Med Chem. 2019 Jan 10;62(1):276-287. doi: 10.1021/acs.jmedchem.8b00368. Epub 2018 Jul 23. J Med Chem. 2019. PMID: 29990428
216 results