Fadl S - Search Results

1

Identification of novel allosteric sites of SARS-CoV-2 papain-like protease (PLpro) for the development of COVID-19 antivirals.

Ferreira JC, Villanueva AJ, Al Adem K, Fadl S, Alzyoud L, Ghattas MA, Rabeh WM. Ferreira JC, et al. Among authors: fadl s. J Biol Chem. 2024 Sep 27;300(11):107821. doi: 10.1016/j.jbc.2024.107821. Online ahead of print. J Biol Chem. 2024. PMID: 39342997 Free PMC article.

2

Catalytic Dyad Residues His41 and Cys145 Impact the Catalytic Activity and Overall Conformational Fold of the Main SARS-CoV-2 Protease 3-Chymotrypsin-Like Protease.

Ferreira JC, Fadl S, Villanueva AJ, Rabeh WM. Ferreira JC, et al. Among authors: fadl s. Front Chem. 2021 Jun 24;9:692168. doi: 10.3389/fchem.2021.692168. eCollection 2021. Front Chem. 2021. PMID: 34249864 Free PMC article.

3

Key dimer interface residues impact the catalytic activity of 3CLpro, the main protease of SARS-CoV-2.

Ferreira JC, Fadl S, Rabeh WM. Ferreira JC, et al. Among authors: fadl s. J Biol Chem. 2022 Jun;298(6):102023. doi: 10.1016/j.jbc.2022.102023. Epub 2022 May 11. J Biol Chem. 2022. PMID: 35568197 Free PMC article.

4

pH profiles of 3-chymotrypsin-like protease (3CLpro) from SARS-CoV-2 elucidate its catalytic mechanism and a histidine residue critical for activity.

Al Adem K, Ferreira JC, Fadl S, Rabeh WM. Al Adem K, et al. Among authors: fadl s. J Biol Chem. 2023 Feb;299(2):102790. doi: 10.1016/j.jbc.2022.102790. Epub 2022 Dec 9. J Biol Chem. 2023. PMID: 36509143 Free PMC article.

5

Residues in the fructose-binding pocket are required for ketohexokinase-A activity.

Ferreira JC, Villanueva AJ, Fadl S, Al Adem K, Cinviz ZN, Nedyalkova L, Cardoso THS, Andrade ME, Saksena NK, Sensoy O, Rabeh WM. Ferreira JC, et al. Among authors: fadl s. J Biol Chem. 2024 Aug;300(8):107538. doi: 10.1016/j.jbc.2024.107538. Epub 2024 Jul 4. J Biol Chem. 2024. PMID: 38971308 Free PMC article.

6

3-chymotrypsin-like protease in SARS-CoV-2.

Al Adem K, Ferreira JC, Villanueva AJ, Fadl S, El-Sadaany F, Masmoudi I, Gidiya Y, Gurudza T, Cardoso THS, Saksena NK, Rabeh WM. Al Adem K, et al. Among authors: fadl s. Biosci Rep. 2024 Aug 28;44(8):BSR20231395. doi: 10.1042/BSR20231395. Biosci Rep. 2024. PMID: 39036877 Free PMC article. Review.

7

Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS-CoV-2 protease 3CLpro.

Ferreira JC, Fadl S, Ilter M, Pekel H, Rezgui R, Sensoy O, Rabeh WM. Ferreira JC, et al. Among authors: fadl s. FASEB J. 2021 Aug;35(8):e21774. doi: 10.1096/fj.202100994. FASEB J. 2021. PMID: 34324734 Free PMC article.

8

Key Allosteric and Active Site Residues of SARS-CoV-2 3CLpro Are Promising Drug Targets.

Al Adem K, Ferreira JC, Fadl S, Mustafa M, Rabeh WM. Al Adem K, et al. Among authors: fadl s. Biochem J. 2023 May 31:BCJ20230027. doi: 10.1042/BCJ20230027. Online ahead of print. Biochem J. 2023. PMID: 37254750

9

Boosting immunity: synergistic antiviral effects of luteolin, vitamin C, magnesium and zinc against SARS-CoV-2 3CLpro.

Ferreira JC, Fadl S, Cardoso THS, Andrade BS, Melo TS, Silva EMA, Agarwal A, Turville SJ, Saksena NK, Rabeh WM. Ferreira JC, et al. Among authors: fadl s. Biosci Rep. 2024 Aug 28;44(8):BSR20240617. doi: 10.1042/BSR20240617. Biosci Rep. 2024. PMID: 39045772 Free PMC article.

10

AFM-compatible microfluidic platform for affinity-based capture and nanomechanical characterization of circulating tumor cells.

Deliorman M, Janahi FK, Sukumar P, Glia A, Alnemari R, Fadl S, Chen W, Qasaimeh MA. Deliorman M, et al. Among authors: fadl s. Microsyst Nanoeng. 2020 Mar 23;6:20. doi: 10.1038/s41378-020-0131-9. eCollection 2020. Microsyst Nanoeng. 2020. PMID: 34567635 Free PMC article.

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