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Page 1
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.
Carling GK, Fan L, Foxe NR, Norman K, Wong MY, Zhu D, Corona C, Razzoli A, Yu F, Yarahmady A, Ye P, Chen H, Huang Y, Amin S, Sereda R, Lopez-Lee C, Zacharioudakis E, Chen X, Xu J, Cheng F, Gavathiotis E, Cuervo AM, Holtzman DM, Mok SA, Sinha SC, Sidoli S, Ratan RR, Luo W, Gong S, Gan L. Carling GK, et al. Among authors: ratan rr. Neuron. 2024 Sep 24:S0896-6273(24)00654-8. doi: 10.1016/j.neuron.2024.09.006. Online ahead of print. Neuron. 2024. PMID: 39353433 Free article.
Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience.
Udeochu JC, Amin S, Huang Y, Fan L, Torres ERS, Carling GK, Liu B, McGurran H, Coronas-Samano G, Kauwe G, Mousa GA, Wong MY, Ye P, Nagiri RK, Lo I, Holtzman J, Corona C, Yarahmady A, Gill MT, Raju RM, Mok SA, Gong S, Luo W, Zhao M, Tracy TE, Ratan RR, Tsai LH, Sinha SC, Gan L. Udeochu JC, et al. Among authors: ratan rr. Nat Neurosci. 2023 May;26(5):737-750. doi: 10.1038/s41593-023-01315-6. Epub 2023 Apr 24. Nat Neurosci. 2023. PMID: 37095396 Free PMC article.
2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer's resilience.
Kumar A, Karuppagounder SS, Chen Y, Corona C, Kawaguchi R, Cheng Y, Balkaya M, Sagdullaev BT, Wen Z, Stuart C, Cho S, Ming GL, Tuvikene J, Timmusk T, Geschwind DH, Ratan RR. Kumar A, et al. Among authors: ratan rr. Neuron. 2023 Sep 20;111(18):2831-2846.e10. doi: 10.1016/j.neuron.2023.06.013. Epub 2023 Jul 14. Neuron. 2023. PMID: 37453419 Free PMC article.
Parkin coregulates glutathione metabolism in adult mammalian brain.
El Kodsi DN, Tokarew JM, Sengupta R, Lengacher NA, Chatterji A, Nguyen AP, Boston H, Jiang Q, Palmberg C, Pileggi C, Holterman CE, Shutinoski B, Li J, Fehr TK, LaVoie MJ, Ratan RR, Shaw GS, Takanashi M, Hattori N, Kennedy CR, Harper ME, Holmgren A, Tomlinson JJ, Schlossmacher MG. El Kodsi DN, et al. Among authors: ratan rr. Acta Neuropathol Commun. 2023 Jan 23;11(1):19. doi: 10.1186/s40478-022-01488-4. Acta Neuropathol Commun. 2023. PMID: 36691076 Free PMC article.
HIF1α stabilization in hypoxia is not oxidant-initiated.
Kumar A, Vaish M, Karuppagounder SS, Gazaryan I, Cave JW, Starkov AA, Anderson ET, Zhang S, Pinto JT, Rountree AM, Wang W, Sweet IR, Ratan RR. Kumar A, et al. Among authors: ratan rr. Elife. 2021 Oct 1;10:e72873. doi: 10.7554/eLife.72873. Elife. 2021. PMID: 34596045 Free PMC article.
158 results