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Insight into the outer membrane asymmetry of P. aeruginosa and the role of MlaA in modulating the lipidic composition, mechanical, biophysical, and functional membrane properties of the cell envelope.
Kaur M, Mozaheb N, Paiva TO, Herent M-F, Goormaghtigh F, Paquot A, Terrasi R, Mignolet E, Décout J-L, Lorent JH, Larondelle Y, Muccioli GG, Quetin-Leclercq J, Dufrêne YF, Mingeot-Leclercq M-P. Kaur M, et al. Among authors: decout j l. Microbiol Spectr. 2024 Nov 5;12(11):e0148424. doi: 10.1128/spectrum.01484-24. Epub 2024 Oct 7. Microbiol Spectr. 2024. PMID: 39373473 Free PMC article.
Deficient Pseudomonas aeruginosa in MlaA/VacJ outer membrane lipoprotein shows decrease in rhamnolipids secretion, motility, and biofilm formation, and increase in fluoroquinolones susceptibility and innate immune response.
Kaur M, Buyck JM, Goormaghtigh F, Decout JL, Mozaheb N, Mingeot-Leclercq MP. Kaur M, et al. Among authors: decout jl. Res Microbiol. 2023 Nov-Dec;174(8):104132. doi: 10.1016/j.resmic.2023.104132. Epub 2023 Sep 1. Res Microbiol. 2023. PMID: 37660742 Free article.
Pharmacological chaperones improve intra-domain stability and inter-domain assembly via distinct binding sites to rescue misfolded CFTR.
Baatallah N, Elbahnsi A, Mornon JP, Chevalier B, Pranke I, Servel N, Zelli R, Décout JL, Edelman A, Sermet-Gaudelus I, Callebaut I, Hinzpeter A. Baatallah N, et al. Among authors: decout jl. Cell Mol Life Sci. 2021 Dec;78(23):7813-7829. doi: 10.1007/s00018-021-03994-5. Epub 2021 Oct 29. Cell Mol Life Sci. 2021. PMID: 34714360 Free PMC article.
Amphiphilic Aminoglycosides as Medicinal Agents.
Dezanet C, Kempf J, Mingeot-Leclercq MP, Décout JL. Dezanet C, et al. Among authors: decout jl. Int J Mol Sci. 2020 Oct 8;21(19):7411. doi: 10.3390/ijms21197411. Int J Mol Sci. 2020. PMID: 33049963 Free PMC article. Review.
Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity.
Froux L, Elbahnsi A, Boucherle B, Billet A, Baatallah N, Hoffmann B, Alliot J, Zelli R, Zeinyeh W, Haudecoeur R, Chevalier B, Fortuné A, Mirval S, Simard C, Lehn P, Mornon JP, Hinzpeter A, Becq F, Callebaut I, Décout JL. Froux L, et al. Among authors: decout jl. Eur J Med Chem. 2020 Mar 15;190:112116. doi: 10.1016/j.ejmech.2020.112116. Epub 2020 Feb 9. Eur J Med Chem. 2020. PMID: 32078860
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