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Page 1
CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodies.
Richard J, Sannier G, Zhu L, Prévost J, Marchitto L, Benlarbi M, Beaudoin-Bussières G, Kim H, Sun Y, Chatterjee D, Medjahed H, Bourassa C, Delgado G-G, Dubé M, Kirchhoff F, Hahn BH, Kumar P, Kaufmann DE, Finzi A. Richard J, et al. Among authors: benlarbi m. mBio. 2024 Nov 13;15(11):e0182724. doi: 10.1128/mbio.01827-24. Epub 2024 Oct 7. mBio. 2024. PMID: 39373535 Free PMC article.
The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity.
Marchitto L, Richard J, Prévost J, Tauzin A, Yang D, Chiu T, Chen HC, Díaz-Salinas MA, Nayrac M, Benlarbi M, Beaudoin-Bussières G, Anand SP, Dionne K, Bélanger É, Chatterjee D, Medjahed H, Bourassa C, Tolbert WD, Hahn BH, Munro JB, Pazgier M, Smith AB 3rd, Finzi A. Marchitto L, et al. Among authors: benlarbi m. bioRxiv [Preprint]. 2024 Jun 7:2024.06.07.597978. doi: 10.1101/2024.06.07.597978. bioRxiv. 2024. Update in: J Virol. 2024 Oct 22;98(10):e0101624. doi: 10.1128/jvi.01016-24 PMID: 38895270 Free PMC article. Updated. Preprint.
NTB-A and 2B4 Natural Killer Cell Receptors Modulate the Capacity of a Cocktail of Non-Neutralizing Antibodies and a Small CD4-Mimetic to Eliminate HIV-1-Infected Cells by Antibody-Dependent Cellular Cytotoxicity.
Marchitto L, Tauzin A, Benlarbi M, Beaudoin-Bussières G, Dionne K, Bélanger É, Chatterjee D, Bourassa C, Medjahed H, Yang D, Chiu TJ, Chen HC, Iii ABS, Richard J, Finzi A. Marchitto L, et al. Among authors: benlarbi m. Viruses. 2024 Jul 20;16(7):1167. doi: 10.3390/v16071167. Viruses. 2024. PMID: 39066329 Free PMC article.
The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity.
Marchitto L, Richard J, Prévost J, Tauzin A, Yang D, Chiu T-J, Chen H-C, Díaz-Salinas MA, Nayrac M, Benlarbi M, Beaudoin-Bussières G, Anand SP, Dionne K, Bélanger É, Chatterjee D, Medjahed H, Bourassa C, Tolbert WD, Hahn BH, Munro JB, Pazgier M, Smith AB 3rd, Finzi A. Marchitto L, et al. Among authors: benlarbi m. J Virol. 2024 Oct 22;98(10):e0101624. doi: 10.1128/jvi.01016-24. Epub 2024 Sep 9. J Virol. 2024. PMID: 39248460
Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120.
Richard J, Prévost J, Bourassa C, Brassard N, Boutin M, Benlarbi M, Goyette G, Medjahed H, Gendron-Lepage G, Gaudette F, Chen HC, Tolbert WD, Smith AB 3rd, Pazgier M, Dubé M, Clark A, Mothes W, Kaufmann DE, Finzi A. Richard J, et al. Among authors: benlarbi m. Cell Chem Biol. 2023 May 18;30(5):540-552.e6. doi: 10.1016/j.chembiol.2023.03.003. Epub 2023 Mar 22. Cell Chem Biol. 2023. PMID: 36958337 Free PMC article.
Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in presence of CD4-mimetics.
Tauzin A, Marchitto L, Bélanger É, Benlarbi M, Beaudoin-Bussières G, Prévost J, Yang D, Chiu TJ, Chen HC, Bourassa C, Medjahed H, Korzeniowski MK, Gottumukkala S, Tolbert WD, Richard J, Smith AB 3rd, Pazgier M, Finzi A. Tauzin A, et al. Among authors: benlarbi m. medRxiv [Preprint]. 2024 Jun 4:2024.06.02.24308281. doi: 10.1101/2024.06.02.24308281. medRxiv. 2024. Update in: J Virol. 2024 Oct 22;98(10):e0096024. doi: 10.1128/jvi.00960-24 PMID: 38883797 Free PMC article. Updated. Preprint.
Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in the presence of CD4-mimetics.
Tauzin A, Marchitto L, Bélanger É, Benlarbi M, Beaudoin-Bussières G, Prévost J, Yang D, Chiu T-J, Chen H-C, Bourassa C, Medjahed H, Korzeniowski MK, Gottumukkala S, Tolbert WD, Richard J, Smith AB 3rd, Pazgier M, Finzi A. Tauzin A, et al. Among authors: benlarbi m. J Virol. 2024 Oct 22;98(10):e0096024. doi: 10.1128/jvi.00960-24. Epub 2024 Sep 4. J Virol. 2024. PMID: 39230306
The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC.
Richard J, Grunst MW, Niu L, Díaz-Salinas MA, Tolbert WD, Marchitto L, Zhou F, Bourassa C, Yang D, Chiu TJ, Chen HC, Benlarbi M; Guillaume-Beaudoin-Buissières; Gottumukkala S, Li W, Dionne K, Bélanger É, Chatterjee D, Medjahed H, Hendrickson WA, Sodroski J, Lang ZC, Morton AJ, Huang RK, Matthies D, Smith AB 3rd, Mothes W, Munro JB, Pazgier M, Finzi A. Richard J, et al. Among authors: benlarbi m. bioRxiv [Preprint]. 2024 Aug 27:2024.08.27.609961. doi: 10.1101/2024.08.27.609961. bioRxiv. 2024. PMID: 39253431 Free PMC article. Preprint.
62 results