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POLCAM: instant molecular orientation microscopy for the life sciences.
Bruggeman E, Zhang O, Needham LM, Körbel M, Daly S, Cheetham M, Peters R, Wu T, Klymchenko AS, Davis SJ, Paluch EK, Klenerman D, Lew MD, O'Holleran K, Lee SF. Bruggeman E, et al. Among authors: needham lm. Nat Methods. 2024 Oct;21(10):1873-1883. doi: 10.1038/s41592-024-02382-8. Epub 2024 Oct 7. Nat Methods. 2024. PMID: 39375574 Free PMC article.
vLUME: 3D virtual reality for single-molecule localization microscopy.
Spark A, Kitching A, Esteban-Ferrer D, Handa A, Carr AR, Needham LM, Ponjavic A, Santos AM, McColl J, Leterrier C, Davis SJ, Henriques R, Lee SF. Spark A, et al. Among authors: needham lm. Nat Methods. 2020 Nov;17(11):1097-1099. doi: 10.1038/s41592-020-0962-1. Epub 2020 Oct 12. Nat Methods. 2020. PMID: 33046895 Free PMC article.
Single-molecule visualization of DNA G-quadruplex formation in live cells.
Di Antonio M, Ponjavic A, Radzevičius A, Ranasinghe RT, Catalano M, Zhang X, Shen J, Needham LM, Lee SF, Klenerman D, Balasubramanian S. Di Antonio M, et al. Among authors: needham lm. Nat Chem. 2020 Sep;12(9):832-837. doi: 10.1038/s41557-020-0506-4. Epub 2020 Jul 20. Nat Chem. 2020. PMID: 32690897 Free PMC article.
ThX - a next-generation probe for the early detection of amyloid aggregates.
Needham LM, Weber J, Varela JA, Fyfe JWB, Do DT, Xu CK, Tutton L, Cliffe R, Keenlyside B, Klenerman D, Dobson CM, Hunter CA, Müller KH, O'Holleran K, Bohndiek SE, Snaddon TN, Lee SF. Needham LM, et al. Chem Sci. 2020 Feb 21;11(18):4578-4583. doi: 10.1039/c9sc04730a. Chem Sci. 2020. PMID: 34122915 Free PMC article.
FRET-enhanced photostability allows improved single-molecule tracking of proteins and protein complexes in live mammalian cells.
Basu S, Needham LM, Lando D, Taylor EJR, Wohlfahrt KJ, Shah D, Boucher W, Tan YL, Bates LE, Tkachenko O, Cramard J, Lagerholm BC, Eggeling C, Hendrich B, Klenerman D, Lee SF, Laue ED. Basu S, et al. Among authors: needham lm. Nat Commun. 2018 Jun 28;9(1):2520. doi: 10.1038/s41467-018-04486-0. Nat Commun. 2018. PMID: 29955052 Free PMC article.
Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation.
Vilalta A, Zhou Y, Sevalle J, Griffin JK, Satoh K, Allendorf DH, De S, Puigdellívol M, Bruzas A, Burguillos MA, Dodd RB, Chen F, Zhang Y, Flagmeier P, Needham LM, Enomoto M, Qamar S, Henderson J, Walter J, Fraser PE, Klenerman D, Lee SF, St George-Hyslop P, Brown GC. Vilalta A, et al. Among authors: needham lm. J Biol Chem. 2021 Jan-Jun;296:100631. doi: 10.1016/j.jbc.2021.100631. Epub 2021 Apr 3. J Biol Chem. 2021. PMID: 33823153 Free PMC article.
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