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Page 1
Structural basis of μ-opioid receptor targeting by a nanobody antagonist.
Yu J, Kumar A, Zhang X, Martin C, Van Holsbeeck K, Raia P, Koehl A, Laeremans T, Steyaert J, Manglik A, Ballet S, Boland A, Stoeber M. Yu J, et al. Among authors: laeremans t. Nat Commun. 2024 Oct 9;15(1):8687. doi: 10.1038/s41467-024-52947-6. Nat Commun. 2024. PMID: 39384768 Free PMC article.
Propagation of conformational changes during μ-opioid receptor activation.
Sounier R, Mas C, Steyaert J, Laeremans T, Manglik A, Huang W, Kobilka BK, Déméné H, Granier S. Sounier R, et al. Among authors: laeremans t. Nature. 2015 Aug 20;524(7565):375-8. doi: 10.1038/nature14680. Epub 2015 Aug 5. Nature. 2015. PMID: 26245377 Free PMC article.
Structural insights into µ-opioid receptor activation.
Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK. Huang W, et al. Among authors: laeremans t. Nature. 2015 Aug 20;524(7565):315-21. doi: 10.1038/nature14886. Epub 2015 Aug 5. Nature. 2015. PMID: 26245379 Free PMC article.
Nanobody-Enabled Reverse Pharmacology on G-Protein-Coupled Receptors.
Pardon E, Betti C, Laeremans T, Chevillard F, Guillemyn K, Kolb P, Ballet S, Steyaert J. Pardon E, et al. Among authors: laeremans t. Angew Chem Int Ed Engl. 2018 May 4;57(19):5292-5295. doi: 10.1002/anie.201712581. Epub 2018 Mar 30. Angew Chem Int Ed Engl. 2018. PMID: 29469969
A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action.
Stoeber M, Jullié D, Lobingier BT, Laeremans T, Steyaert J, Schiller PW, Manglik A, von Zastrow M. Stoeber M, et al. Among authors: laeremans t. Neuron. 2018 Jun 6;98(5):963-976.e5. doi: 10.1016/j.neuron.2018.04.021. Epub 2018 May 10. Neuron. 2018. PMID: 29754753 Free PMC article.
Structural insights into the activation of metabotropic glutamate receptors.
Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK. Koehl A, et al. Among authors: laeremans t. Nature. 2019 Feb;566(7742):79-84. doi: 10.1038/s41586-019-0881-4. Epub 2019 Jan 23. Nature. 2019. PMID: 30675062 Free PMC article.
Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.
Sigoillot M, Overtus M, Grodecka M, Scholl D, Garcia-Pino A, Laeremans T, He L, Pardon E, Hildebrandt E, Urbatsch I, Steyaert J, Riordan JR, Govaerts C. Sigoillot M, et al. Among authors: laeremans t. Nat Commun. 2019 Jun 14;10(1):2636. doi: 10.1038/s41467-019-10714-y. Nat Commun. 2019. PMID: 31201318 Free PMC article.
Author Correction: Structural insights into μ-opioid receptor activation.
Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK. Huang W, et al. Among authors: laeremans t. Nature. 2020 Aug;584(7820):E16. doi: 10.1038/s41586-020-2542-z. Nature. 2020. PMID: 32724208
A general protocol for the generation of Nanobodies for structural biology.
Pardon E, Laeremans T, Triest S, Rasmussen SG, Wohlkönig A, Ruf A, Muyldermans S, Hol WG, Kobilka BK, Steyaert J. Pardon E, et al. Among authors: laeremans t. Nat Protoc. 2014 Mar;9(3):674-93. doi: 10.1038/nprot.2014.039. Epub 2014 Feb 27. Nat Protoc. 2014. PMID: 24577359 Free PMC article.
45 results