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Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer's disease.
Naderi Yeganeh P, Kwak SS, Jorfi M, Koler K, Kalatturu T, von Maydell D, Liu Z, Guo K, Choi Y, Park J, Abarca N, Bakiasi G, Cetinbas M, Sadreyev R, Griciuc A, Quinti L, Choi SH, Xia W, Tanzi RE, Hide W, Kim DY. Naderi Yeganeh P, et al. Among authors: griciuc a. Neuron. 2024 Nov 25:S0896-6273(24)00800-6. doi: 10.1016/j.neuron.2024.10.029. Online ahead of print. Neuron. 2024. PMID: 39610246
Expression-based selection identifies a microglia-tropic AAV capsid for direct and CSF routes of administration in mice.
Santoscoy MC, Espinoza P, Hanlon KS, Yang L, Nieland L, Ng C, Badr CE, Hickman S, de la Cruz D, Griciuc A, Elkhoury J, Bennett RE, Shen S, Maguire CA. Santoscoy MC, et al. Among authors: griciuc a. bioRxiv [Preprint]. 2024 Sep 27:2024.09.25.614546. doi: 10.1101/2024.09.25.614546. bioRxiv. 2024. PMID: 39386560 Free PMC article. Preprint.
Gene therapy for CNS disorders: modalities, delivery and translational challenges.
Gao J, Gunasekar S, Xia ZJ, Shalin K, Jiang C, Chen H, Lee D, Lee S, Pisal ND, Luo JN, Griciuc A, Karp JM, Tanzi R, Joshi N. Gao J, et al. Among authors: griciuc a. Nat Rev Neurosci. 2024 Aug;25(8):553-572. doi: 10.1038/s41583-024-00829-7. Epub 2024 Jun 19. Nat Rev Neurosci. 2024. PMID: 38898231 Review.
Evaluation of bumetanide as a potential therapeutic agent for Alzheimer's disease.
Boyarko B, Podvin S, Greenberg B, Momper JD, Huang Y, Gerwick WH, Bang AG, Quinti L, Griciuc A, Kim DY, Tanzi RE, Feldman HH, Hook V. Boyarko B, et al. Among authors: griciuc a. Front Pharmacol. 2023 Aug 4;14:1190402. doi: 10.3389/fphar.2023.1190402. eCollection 2023. Front Pharmacol. 2023. PMID: 37601062 Free PMC article. Review.
Natural medicine HLXL targets multiple pathways of amyloid-mediated neuroinflammation and immune response in treating alzheimer's disease.
Liang Y, Lee DYW, Zhen S, Sun H, Zhu B, Liu J, Lei D, Lin CJ, Zhang S, Jacques NA, Quinti L, Ran C, Wang C, Griciuc A, Choi SH, Dai RH, Efferth T, Tanzi RE, Zhang C. Liang Y, et al. Among authors: griciuc a. Phytomedicine. 2022 Sep;104:154158. doi: 10.1016/j.phymed.2022.154158. Epub 2022 May 13. Phytomedicine. 2022. PMID: 35728383
Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease.
McAlpine CS, Park J, Griciuc A, Kim E, Choi SH, Iwamoto Y, Kiss MG, Christie KA, Vinegoni C, Poller WC, Mindur JE, Chan CT, He S, Janssen H, Wong LP, Downey J, Singh S, Anzai A, Kahles F, Jorfi M, Feruglio PF, Sadreyev RI, Weissleder R, Kleinstiver BP, Nahrendorf M, Tanzi RE, Swirski FK. McAlpine CS, et al. Among authors: griciuc a. Nature. 2021 Jul;595(7869):701-706. doi: 10.1038/s41586-021-03734-6. Epub 2021 Jul 14. Nature. 2021. PMID: 34262178 Free PMC article.
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