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Intranasal immunization with CPAF combined with cyclic-di-AMP induces a memory CD4 T cell response and reduces bacterial burden following intravaginal infection with Chlamydia muridarum.
Poston TB, Girardi J, Kim M, Zwarycz P, Polson AG, Yount K, Hanlan C, Salas IJ, Lammert SM, Arroyo D, Bruno T, Wu M, Rozzelle J, Fairman J, Esser-Kahn A, Darville T. Poston TB, et al. Among authors: darville t. bioRxiv [Preprint]. 2024 Sep 24:2024.09.20.614154. doi: 10.1101/2024.09.20.614154. bioRxiv. 2024. Update in: Vaccine. 2024 Nov 12;43(Pt 1):126526. doi: 10.1016/j.vaccine.2024.126526. PMID: 39386616 Free PMC article. Updated. Preprint.
Viral-vectored boosting of OmcB- or CPAF-specific T-cell responses fail to enhance protection from Chlamydia muridarum in infection-immune mice and elicits a non-protective CD8-dominant response in naïve mice.
Poston TB, Girardi J, Polson AG, Bhardwaj A, Yount KS, Jaras Salas I, Trim LK, Li Y, O'Connell CM, Leahy D, Harris JM, Beagley KW, Goonetilleke N, Darville T. Poston TB, et al. Among authors: darville t. Mucosal Immunol. 2024 Oct;17(5):1005-1018. doi: 10.1016/j.mucimm.2024.06.012. Epub 2024 Jul 3. Mucosal Immunol. 2024. PMID: 38969067 Free PMC article.
Chlamydia trachomatis induces low-frequency, sustained CD4 T cell responses in most women, predominantly targeting chlamydial protease-like activity factor, CPAF.
Li Y, Warren JA, Poston TB, Clutton G, Shaw FR, Conrad SZ, Xu Y, Zheng X, Yount KS, O'Connell CM, Wiesenfeld HC, Darville T, Goonetilleke N. Li Y, et al. Among authors: darville t. J Infect Dis. 2024 Sep 9:jiae443. doi: 10.1093/infdis/jiae443. Online ahead of print. J Infect Dis. 2024. PMID: 39250505
Intranasal immunization with CPAF combined with ADU-S100 induces an effector CD4 T cell response and reduces bacterial burden following intravaginal infection with Chlamydia muridarum.
Poston TB, Girardi J, Kim M, Zwarycz P, Polson AG, Yount KS, Hanlan C, Jaras Salas I, Lammert SM, Arroyo D, Bruno T, Wu M, Rozzelle J, Fairman J, Esser-Kahn AP, Darville T. Poston TB, et al. Among authors: darville t. Vaccine. 2024 Nov 12;43(Pt 1):126526. doi: 10.1016/j.vaccine.2024.126526. Online ahead of print. Vaccine. 2024. PMID: 39536454 Free article.
Plasmid-mediated virulence in Chlamydia.
Turman BJ, Darville T, O'Connell CM. Turman BJ, et al. Among authors: darville t. Front Cell Infect Microbiol. 2023 Aug 17;13:1251135. doi: 10.3389/fcimb.2023.1251135. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37662000 Free PMC article. Review.
A Machine Learning-Based Analytic Pipeline Applied to Clinical and Serum IgG Immunoproteome Data To Predict Chlamydia trachomatis Genital Tract Ascension and Incident Infection in Women.
Liu C, Mokashi NV, Darville T, Sun X, O'Connell CM, Hufnagel K, Waterboer T, Zheng X. Liu C, et al. Among authors: darville t. Microbiol Spectr. 2023 Aug 17;11(4):e0468922. doi: 10.1128/spectrum.04689-22. Epub 2023 Jun 15. Microbiol Spectr. 2023. PMID: 37318345 Free PMC article.
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