Meagher J - Search Results

1

Second-Generation Cap Analogue Prodrugs for Targeting Aberrant Eukaryotic Translation Initiation Factor 4E (eIF4E) Activity in Drug-Resistant Melanoma.

Cárdenas EL, O'Rourke RL, Menon A, Vega-Hernández G, Meagher J, Stuckey J, Garner AL. Cárdenas EL, et al. Among authors: meagher j. bioRxiv [Preprint]. 2024 Sep 27:2024.09.25.614990. doi: 10.1101/2024.09.25.614990. bioRxiv. 2024. PMID: 39386734 Free PMC article. Preprint.

2

HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry.

Pham VV, Salguero C, Khan SN, Meagher JL, Brown WC, Humbert N, de Rocquigny H, Smith JL, D'Souza VM. Pham VV, et al. Nat Commun. 2018 Oct 15;9(1):4266. doi: 10.1038/s41467-018-06591-6. Nat Commun. 2018. PMID: 30323330 Free PMC article.

3

A structure-based mechanism for displacement of the HEXIM adapter from 7SK small nuclear RNA.

Pham VV, Gao M, Meagher JL, Smith JL, D'Souza VM. Pham VV, et al. Among authors: meagher jl. Commun Biol. 2022 Aug 15;5(1):819. doi: 10.1038/s42003-022-03734-w. Commun Biol. 2022. PMID: 35970937 Free PMC article.

4

Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer.

Cárdenas EL, O'Rourke RL, Menon A, Meagher J, Stuckey J, Garner AL. Cárdenas EL, et al. Among authors: meagher j. bioRxiv [Preprint]. 2023 May 24:2023.05.23.541912. doi: 10.1101/2023.05.23.541912. bioRxiv. 2023. Update in: J Med Chem. 2023 Aug 10;66(15):10734-10745. doi: 10.1021/acs.jmedchem.3c00917 PMID: 37292917 Free PMC article. Updated. Preprint.

5

Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer.

Cárdenas EL, O'Rourke RL, Menon A, Meagher J, Stuckey J, Garner AL. Cárdenas EL, et al. Among authors: meagher j. J Med Chem. 2023 Aug 10;66(15):10734-10745. doi: 10.1021/acs.jmedchem.3c00917. Epub 2023 Jul 20. J Med Chem. 2023. PMID: 37471629 Free PMC article.

6

Discovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression.

Xu R, Zhou H, Bai L, McEachern D, Wu D, Acharyya RK, Wang M, Tošović J, Yang CY, Chinnaswamy K, Meagher JL, Stuckey JA, Liu C, Wang M, Wen B, Sun D, Wang S. Xu R, et al. Among authors: meagher jl. J Med Chem. 2024 Nov 28;67(22):20495-20513. doi: 10.1021/acs.jmedchem.4c01946. Epub 2024 Nov 7. J Med Chem. 2024. PMID: 39509603

7

Crystal structure of banana lectin reveals a novel second sugar binding site.

Meagher JL, Winter HC, Ezell P, Goldstein IJ, Stuckey JA. Meagher JL, et al. Glycobiology. 2005 Oct;15(10):1033-42. doi: 10.1093/glycob/cwi088. Epub 2005 Jun 8. Glycobiology. 2005. PMID: 15944373

8

Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.

Wang G, Nikolovska-Coleska Z, Yang CY, Wang R, Tang G, Guo J, Shangary S, Qiu S, Gao W, Yang D, Meagher J, Stuckey J, Krajewski K, Jiang S, Roller PP, Abaan HO, Tomita Y, Wang S. Wang G, et al. Among authors: meagher j. J Med Chem. 2006 Oct 19;49(21):6139-42. doi: 10.1021/jm060460o. J Med Chem. 2006. PMID: 17034116

9

Design, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimetic.

Sun H, Nikolovska-Coleska Z, Lu J, Qiu S, Yang CY, Gao W, Meagher J, Stuckey J, Wang S. Sun H, et al. Among authors: meagher j. J Med Chem. 2006 Dec 28;49(26):7916-20. doi: 10.1021/jm061108d. J Med Chem. 2006. PMID: 17181177

10

Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins.

Tang G, Ding K, Nikolovska-Coleska Z, Yang CY, Qiu S, Shangary S, Wang R, Guo J, Gao W, Meagher J, Stuckey J, Krajewski K, Jiang S, Roller PP, Wang S. Tang G, et al. Among authors: meagher j. J Med Chem. 2007 Jul 12;50(14):3163-6. doi: 10.1021/jm070383c. Epub 2007 Jun 7. J Med Chem. 2007. PMID: 17552510 Free PMC article.

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