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Nicorandil antiallodynic activity in a model of neuropathic pain is associated with the activation of ATP-dependent potassium channels and opioidergic pathways, and reduced production of cytokines and neutrophils recruitment in paw, sciatic nerve, and dorsal root ganglia.
Braga AV, Morais MÍ, Delfino DGS, Costa SOAM, Barbosa BCM, Rodrigues FF, Melo ISF, Matos RC, Castro BFM, Cunha Júnior AS, Braga TC, de Fátima Â, Coelho MM, Machado RR. Braga AV, et al. Among authors: de fatima a. Pharmacol Rep. 2024 Oct;76(5):1067-1078. doi: 10.1007/s43440-024-00640-2. Epub 2024 Aug 23. Pharmacol Rep. 2024. PMID: 39179890
The new psychoactive substances 25H-NBOMe and 25H-NBOH induce abnormal development in the zebrafish embryo and interact in the DNA major groove.
de Barros WA, Nunes CDS, Souza JADCR, Nascimento IJDS, Figueiredo IM, de Aquino TM, Vieira L, Farias D, Santos JCC, de Fátima Â. de Barros WA, et al. Among authors: de aquino tm, de fatima a. Curr Res Toxicol. 2021 Nov 22;2:386-398. doi: 10.1016/j.crtox.2021.11.002. eCollection 2021. Curr Res Toxicol. 2021. PMID: 34888530 Free PMC article.
101 results