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Design and Preclinical Evaluation of a Novel B7-H4-Directed Antibody-Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305.
Kinneer K, Wortmann P, Cooper ZA, Dickinson NJ, Masterson L, Cailleau T, Hutchinson I, Vijayakrishnan B, McFarlane M, Ball K, Davies M, Lewis A, Huang Y, Rosenbaum AI, Yuan J, Chesebrough J, Anderton J, Monks N, Novick S, Wang J, Dimasi N, Christie RJ, Sabol D, Tosto FA, Wallez Y, Leo E, Albertella MR, Staniszewska AD, Tice DA, Howard PW, Luheshi N, Sapra P. Kinneer K, et al. Among authors: huang y. Clin Cancer Res. 2023 Mar 14;29(6):1086-1101. doi: 10.1158/1078-0432.CCR-22-2630. Clin Cancer Res. 2023. PMID: 36355054
Multifaceted Bioanalytical Methods for the Comprehensive Pharmacokinetic and Catabolic Assessment of MEDI3726, an Anti-Prostate-Specific Membrane Antigen Pyrrolobenzodiazepine Antibody-Drug Conjugate.
Huang Y, Del Nagro CJ, Balic K, Mylott WR Jr, Ismaiel OA, Ma E, Faria M, Wheeler AM, Yuan M, Waldron MP, Peay MG, Cortes DF, Roskos L, Liang M, Rosenbaum AI. Huang Y, et al. Anal Chem. 2020 Aug 18;92(16):11135-11144. doi: 10.1021/acs.analchem.0c01187. Epub 2020 Jul 1. Anal Chem. 2020. PMID: 32459957 Free article. Clinical Trial.
Multiplex Hybrid Antigen-Capture LC-MRM Quantification in Sera and Nasal Lining Fluid of AZD7442, a SARS-CoV-2-Targeting Antibody Combination.
Mu R, Huang Y, Bouquet J, Yuan J, Kubiak RJ, Ma E, Naser S, Mylott WR Jr, Ismaiel OA, Wheeler AM, Burkart R, Cortes DF, Bruton J, Arends RH, Liang M, Rosenbaum AI. Mu R, et al. Among authors: huang y. Anal Chem. 2022 Nov 1;94(43):14835-14845. doi: 10.1021/acs.analchem.2c01320. Epub 2022 Oct 21. Anal Chem. 2022. PMID: 36269894 Free PMC article.
Multiplex Bioanalytical Methods for Comprehensive Characterization and Quantification of the Unique Complementarity-Determining-Region Deamidation of MEDI7247, an Anti-ASCT2 Pyrrolobenzodiazepine Antibody-Drug Conjugate.
Huang Y, Yuan J, Mu R, Kubiak RJ, Ball K, Cao M, Hussmann GP, de Mel N, Liu D, Roskos LK, Liang M, Rosenbaum AI. Huang Y, et al. Antibodies (Basel). 2023 Oct 17;12(4):66. doi: 10.3390/antib12040066. Antibodies (Basel). 2023. PMID: 37873863 Free PMC article.
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