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Head-to-head comparison of leading blood tests for Alzheimer's disease pathology.
Schindler SE, Petersen KK, Saef B, Tosun D, Shaw LM, Zetterberg H, Dage JL, Ferber K, Triana-Baltzer G, Du-Cuny L, Li Y, Coomaraswamy J, Baratta M, Mordashova Y, Saad ZS, Raunig DL, Ashton NJ, Meyers EA, Rubel CE, Rosenbaugh EG, Bannon AW, Potter WZ; Alzheimer's Disease Neuroimaging Initiative (ADNI) Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium Plasma Aβ and Phosphorylated Tau as Predictors of Amyloid and Tau Positivity in Alzheimer's Disease Project Team. Schindler SE, et al. Among authors: coomaraswamy j. Alzheimers Dement. 2024 Nov;20(11):8074-8096. doi: 10.1002/alz.14315. Epub 2024 Oct 12. Alzheimers Dement. 2024. PMID: 39394841 Free PMC article.
Head-to-head comparison of leading blood tests for Alzheimer's disease pathology.
Schindler SE, Petersen KK, Saef B, Tosun D, Shaw LM, Zetterberg H, Dage JL, Ferber K, Triana-Baltzer G, Du-Cuny L, Li Y, Coomaraswamy J, Baratta M, Mordashova Y, Saad ZS, Raunig DL, Ashton NJ, Meyers EA, Rubel CE, Rosenbaugh EG, Bannon AW, Potter WZ. Schindler SE, et al. Among authors: coomaraswamy j. medRxiv [Preprint]. 2024 Jul 3:2024.06.12.24308839. doi: 10.1101/2024.06.12.24308839. medRxiv. 2024. Update in: Alzheimers Dement. 2024 Nov;20(11):8074-8096. doi: 10.1002/alz.14315 PMID: 38946970 Free PMC article. Updated. Preprint.
Timing of changes in Alzheimer's disease plasma biomarkers as assessed by amyloid and tau PET clocks.
Milà-Alomà M, Tosun D, Schindler SE, Hausle Z, Li Y, Petersen KK, Dage JL, Du-Cuny L, Saad ZS, Saef B, Triana-Baltzer G, Raunig DL, Coomaraswamy J, Baratta M, Meyers EA, Mordashova Y, Rubel CE, Ferber K, Kolb H, Ashton NJ, Zetterberg H, Rosenbaugh EG, Sabandal M, Shaw LM, Bannon AW, Potter WZ; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium Plasma Aβ and Phosphorylated Tau as Predictors of Amyloid and Tau Positivity in Alzheimer’s Disease Project Team. Milà-Alomà M, et al. Among authors: coomaraswamy j. medRxiv [Preprint]. 2024 Nov 14:2024.10.25.24316144. doi: 10.1101/2024.10.25.24316144. medRxiv. 2024. PMID: 39574864 Free PMC article. Preprint.
Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation In Vivo.
Jones JH, Xin Z, Himmelbauer M, Dechantsreiter M, Enyedy I, Hedde J, Fang T, Coomaraswamy J, King KW, Murugan P, Santoro JC, Hesson T, Walther DM, Wei R, Zheng F, Marcotte DJ, Spilker K, Kumar PR, Liu Y, Gilfillan R, Gonzalez-Lopez de Turiso F. Jones JH, et al. Among authors: coomaraswamy j. J Med Chem. 2021 Oct 28;64(20):15402-15419. doi: 10.1021/acs.jmedchem.1c01458. Epub 2021 Oct 15. J Med Chem. 2021. PMID: 34653340
No dopamine cell loss or changes in cytoskeleton function in transgenic mice expressing physiological levels of wild type or G2019S mutant LRRK2 and in human fibroblasts.
Garcia-Miralles M, Coomaraswamy J, Häbig K, Herzig MC, Funk N, Gillardon F, Maisel M, Jucker M, Gasser T, Galter D, Biskup S. Garcia-Miralles M, et al. Among authors: coomaraswamy j. PLoS One. 2015 Apr 1;10(4):e0118947. doi: 10.1371/journal.pone.0118947. eCollection 2015. PLoS One. 2015. PMID: 25830304 Free PMC article.
Endoproteolytic processing of the mammalian prion glycoprotein family.
Mays CE, Coomaraswamy J, Watts JC, Yang J, Ko KW, Strome B, Mercer RC, Wohlgemuth SL, Schmitt-Ulms G, Westaway D. Mays CE, et al. Among authors: coomaraswamy j. FEBS J. 2014 Feb;281(3):862-76. doi: 10.1111/febs.12654. Epub 2013 Dec 23. FEBS J. 2014. PMID: 24286250 Free article.
Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to PrP(Sc) accumulation.
Westaway D, Genovesi S, Daude N, Brown R, Lau A, Lee I, Mays CE, Coomaraswamy J, Canine B, Pitstick R, Herbst A, Yang J, Ko KW, Schmitt-Ulms G, Dearmond SJ, McKenzie D, Hood L, Carlson GA. Westaway D, et al. Among authors: coomaraswamy j. PLoS Pathog. 2011 Nov;7(11):e1002391. doi: 10.1371/journal.ppat.1002391. Epub 2011 Nov 17. PLoS Pathog. 2011. PMID: 22114562 Free PMC article.
Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.
Coomaraswamy J, Kilger E, Wölfing H, Schäfer C, Kaeser SA, Wegenast-Braun BM, Hefendehl JK, Wolburg H, Mazzella M, Ghiso J, Goedert M, Akiyama H, Garcia-Sierra F, Wolfer DP, Mathews PM, Jucker M. Coomaraswamy J, et al. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7969-74. doi: 10.1073/pnas.1001056107. Epub 2010 Apr 12. Proc Natl Acad Sci U S A. 2010. PMID: 20385796 Free PMC article.
20 results