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Page 1
Pharmacology of PIEZO1 channels.
Kinsella JA, Debant M, Parsonage G, Morley LC, Bajarwan M, Revill C, Foster R, Beech DJ. Kinsella JA, et al. Among authors: foster r. Br J Pharmacol. 2024 Dec;181(23):4714-4732. doi: 10.1111/bph.17351. Epub 2024 Oct 14. Br J Pharmacol. 2024. PMID: 39402010 Review.
Improved PIEZO1 agonism through 4-benzoic acid modification of Yoda1.
Parsonage G, Cuthbertson K, Endesh N, Murciano N, Hyman AJ, Revill CH, Povstyan OV, Chuntharpursat-Bon E, Debant M, Ludlow MJ, Futers TS, Lichtenstein L, Kinsella JA, Bartoli F, Rotordam MG, Becker N, Brüggemann A, Foster R, Beech DJ. Parsonage G, et al. Among authors: foster r. Br J Pharmacol. 2023 Aug;180(16):2039-2063. doi: 10.1111/bph.15996. Epub 2023 Jan 31. Br J Pharmacol. 2023. PMID: 36457143 Free PMC article.
Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance.
Rode B, Shi J, Endesh N, Drinkhill MJ, Webster PJ, Lotteau SJ, Bailey MA, Yuldasheva NY, Ludlow MJ, Cubbon RM, Li J, Futers TS, Morley L, Gaunt HJ, Marszalek K, Viswambharan H, Cuthbertson K, Baxter PD, Foster R, Sukumar P, Weightman A, Calaghan SC, Wheatcroft SB, Kearney MT, Beech DJ. Rode B, et al. Among authors: foster r. Nat Commun. 2017 Aug 24;8(1):350. doi: 10.1038/s41467-017-00429-3. Nat Commun. 2017. PMID: 28839146 Free PMC article.
Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion.
Blythe NM, Muraki K, Ludlow MJ, Stylianidis V, Gilbert HTJ, Evans EL, Cuthbertson K, Foster R, Swift J, Li J, Drinkhill MJ, van Nieuwenhoven FA, Porter KE, Beech DJ, Turner NA. Blythe NM, et al. Among authors: foster r. J Biol Chem. 2019 Nov 15;294(46):17395-17408. doi: 10.1074/jbc.RA119.009167. Epub 2019 Oct 4. J Biol Chem. 2019. PMID: 31586031 Free PMC article.
Independent endothelial functions of PIEZO1 and TRPV4 in hepatic portal vein and predominance of PIEZO1 in mechanical and osmotic stress.
Endesh N, Chuntharpursat-Bon E, Revill C, Yuldasheva NY, Futers TS, Parsonage G, Humphreys N, Adamson A, Morley LC, Cubbon RM, Prasad KR, Foster R, Lichtenstein L, Beech DJ. Endesh N, et al. Among authors: foster r. Liver Int. 2023 Sep;43(9):2026-2038. doi: 10.1111/liv.15646. Epub 2023 Jun 22. Liver Int. 2023. PMID: 37349903 Free PMC article.
Piezo1 channel activation mimics high glucose as a stimulator of insulin release.
Deivasikamani V, Dhayalan S, Abudushalamu Y, Mughal R, Visnagri A, Cuthbertson K, Scragg JL, Munsey TS, Viswambharan H, Muraki K, Foster R, Sivaprasadarao A, Kearney MT, Beech DJ, Sukumar P. Deivasikamani V, et al. Among authors: foster r. Sci Rep. 2019 Nov 14;9(1):16876. doi: 10.1038/s41598-019-51518-w. Sci Rep. 2019. PMID: 31727906 Free PMC article.
2,400 results