Asano R - Search Results

1

Construction of bispecific antibodies by specific pairing between the heavy chain and the light chain using removable SpyCatcher/SnoopCatcher units.

Yoshida J, Kato Y, Isogawa A, Tanaka Y, Kumagai I, Asano R, Nakanishi T, Makabe K. Yoshida J, et al. Among authors: asano r. J Biol Eng. 2024 Oct 14;18(1):57. doi: 10.1186/s13036-024-00454-z. J Biol Eng. 2024. PMID: 39402666 Free PMC article.

2

Highly effective recombinant format of a humanized IgG-like bispecific antibody for cancer immunotherapy with retargeting of lymphocytes to tumor cells.

Asano R, Watanabe Y, Kawaguchi H, Fukazawa H, Nakanishi T, Umetsu M, Hayashi H, Katayose Y, Unno M, Kudo T, Kumagai I. Asano R, et al. J Biol Chem. 2007 Sep 21;282(38):27659-65. doi: 10.1074/jbc.M704719200. Epub 2007 Jul 19. J Biol Chem. 2007. PMID: 17644522 Free article.

3

Thermodynamic consequences of mutations in vernier zone residues of a humanized anti-human epidermal growth factor receptor murine antibody, 528.

Makabe K, Nakanishi T, Tsumoto K, Tanaka Y, Kondo H, Umetsu M, Sone Y, Asano R, Kumagai I. Makabe K, et al. Among authors: asano r. J Biol Chem. 2008 Jan 11;283(2):1156-66. doi: 10.1074/jbc.M706190200. Epub 2007 Oct 17. J Biol Chem. 2008. PMID: 17947238 Free article.

4

Preferential heterodimerization of a bispecific diabody based on a humanized anti-EGFR antibody 528.

Asano R, Sone Y, Ikoma K, Hayashi H, Nakanishi T, Umetsu M, Katayose Y, Unno M, Kudo T, Kumagai I. Asano R, et al. Protein Eng Des Sel. 2008 Oct;21(10):597-603. doi: 10.1093/protein/gzn037. Epub 2008 Jul 11. Protein Eng Des Sel. 2008. PMID: 18621782

5

Highly enhanced cytotoxicity of a dimeric bispecific diabody, the hEx3 tetrabody.

Asano R, Ikoma K, Sone Y, Kawaguchi H, Taki S, Hayashi H, Nakanishi T, Umetsu M, Katayose Y, Unno M, Kudo T, Kumagai I. Asano R, et al. J Biol Chem. 2010 Jul 2;285(27):20844-9. doi: 10.1074/jbc.M110.120444. Epub 2010 May 5. J Biol Chem. 2010. PMID: 20444691 Free PMC article.

6

Cytotoxic enhancement of a bispecific diabody by format conversion to tandem single-chain variable fragment (taFv): the case of the hEx3 diabody.

Asano R, Ikoma K, Shimomura I, Taki S, Nakanishi T, Umetsu M, Kumagai I. Asano R, et al. J Biol Chem. 2011 Jan 21;286(3):1812-8. doi: 10.1074/jbc.M110.172957. Epub 2010 Nov 19. J Biol Chem. 2011. PMID: 21097496 Free PMC article.

7

Development of an affinity-matured humanized anti-epidermal growth factor receptor antibody for cancer immunotherapy.

Nakanishi T, Maru T, Tahara K, Sanada H, Umetsu M, Asano R, Kumagai I. Nakanishi T, et al. Among authors: asano r. Protein Eng Des Sel. 2013 Feb;26(2):113-22. doi: 10.1093/protein/gzs088. Epub 2012 Oct 31. Protein Eng Des Sel. 2013. PMID: 23118340

8

[Functionalization of Bispecific Therapeutic Antibodies Based on Protein Engineering].

Asano R, Kumagai I. Asano R, et al. Yakugaku Zasshi. 2015;135(7):851-6. doi: 10.1248/yakushi.15-00007-2. Yakugaku Zasshi. 2015. PMID: 26135084 Free article. Review. Japanese.

9

Generation of camelid VHH bispecific constructs via in-cell intein-mediated protein trans-splicing.

Shibuya Y, Haga N, Asano R, Nakazawa H, Hattori T, Takeda D, Sugiyama A, Kurotani R, Kumagai I, Umetsu M, Makabe K. Shibuya Y, et al. Among authors: asano r. Protein Eng Des Sel. 2017 Jan;30(1):15-21. doi: 10.1093/protein/gzw057. Epub 2016 Nov 23. Protein Eng Des Sel. 2017. PMID: 27881685

10

Structural considerations for functional anti-EGFR × anti-CD3 bispecific diabodies in light of domain order and binding affinity.

Asano R, Nagai K, Makabe K, Takahashi K, Kumagai T, Kawaguchi H, Ogata H, Arai K, Umetsu M, Kumagai I. Asano R, et al. Oncotarget. 2018 Feb 14;9(17):13884-13893. doi: 10.18632/oncotarget.24490. eCollection 2018 Mar 2. Oncotarget. 2018. PMID: 29568402 Free PMC article.

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