Jordan DM - Search Results

1

Expanding drug targets for 112 chronic diseases using a machine learning-assisted genetic priority score.

Chen R, Duffy Á, Petrazzini BO, Vy HM, Stein D, Mort M, Park JK, Schlessinger A, Itan Y, Cooper DN, Jordan DM, Rocheleau G, Do R. Chen R, et al. Among authors: jordan dm. Nat Commun. 2024 Oct 15;15(1):8891. doi: 10.1038/s41467-024-53333-y. Nat Commun. 2024. PMID: 39406732 Free PMC article.

2

Machine learning-based marker for coronary artery disease: derivation and validation in two longitudinal cohorts.

Forrest IS, Petrazzini BO, Duffy Á, Park JK, Marquez-Luna C, Jordan DM, Rocheleau G, Cho JH, Rosenson RS, Narula J, Nadkarni GN, Do R. Forrest IS, et al. Among authors: jordan dm. Lancet. 2023 Jan 21;401(10372):215-225. doi: 10.1016/S0140-6736(22)02079-7. Epub 2022 Dec 20. Lancet. 2023. PMID: 36563696 Free PMC article.

3

A machine learning model identifies patients in need of autoimmune disease testing using electronic health records.

Forrest IS, Petrazzini BO, Duffy Á, Park JK, O'Neal AJ, Jordan DM, Rocheleau G, Nadkarni GN, Cho JH, Blazer AD, Do R. Forrest IS, et al. Among authors: jordan dm. Nat Commun. 2023 Apr 25;14(1):2385. doi: 10.1038/s41467-023-37996-7. Nat Commun. 2023. PMID: 37169741 Free PMC article.

4

Development of a human genetics-guided priority score for 19,365 genes and 399 drug indications.

Duffy Á, Petrazzini BO, Stein D, Park JK, Forrest IS, Gibson K, Vy HM, Chen R, Márquez-Luna C, Mort M, Verbanck M, Schlessinger A, Itan Y, Cooper DN, Rocheleau G, Jordan DM, Do R. Duffy Á, et al. Among authors: jordan dm. Nat Genet. 2024 Jan;56(1):51-59. doi: 10.1038/s41588-023-01609-2. Epub 2024 Jan 3. Nat Genet. 2024. PMID: 38172303

5

Exome sequence analysis identifies rare coding variants associated with a machine learning-based marker for coronary artery disease.

Petrazzini BO, Forrest IS, Rocheleau G, Vy HMT, Márquez-Luna C, Duffy Á, Chen R, Park JK, Gibson K, Goonewardena SN, Malick WA, Rosenson RS, Jordan DM, Do R. Petrazzini BO, et al. Among authors: jordan dm. Nat Genet. 2024 Jul;56(7):1412-1419. doi: 10.1038/s41588-024-01791-x. Epub 2024 Jun 11. Nat Genet. 2024. PMID: 38862854

6

Using Full Genomic Information to Predict Disease: Breaking Down the Barriers Between Complex and Mendelian Diseases.

Jordan DM, Do R. Jordan DM, et al. Annu Rev Genomics Hum Genet. 2018 Aug 31;19:289-301. doi: 10.1146/annurev-genom-083117-021136. Epub 2018 Apr 11. Annu Rev Genomics Hum Genet. 2018. PMID: 29641912 Review.

7

HOPS: a quantitative score reveals pervasive horizontal pleiotropy in human genetic variation is driven by extreme polygenicity of human traits and diseases.

Jordan DM, Verbanck M, Do R. Jordan DM, et al. Genome Biol. 2019 Oct 25;20(1):222. doi: 10.1186/s13059-019-1844-7. Genome Biol. 2019. PMID: 31653226 Free PMC article.

8

Probing the aggregated effects of purifying selection per individual on 1,380 medical phenotypes in the UK Biobank.

Vy HMT, Jordan DM, Balick DJ, Do R. Vy HMT, et al. Among authors: jordan dm. PLoS Genet. 2021 Jan 25;17(1):e1009337. doi: 10.1371/journal.pgen.1009337. eCollection 2021 Jan. PLoS Genet. 2021. PMID: 33493176 Free PMC article.

9

Population-Based Penetrance of Deleterious Clinical Variants.

Forrest IS, Chaudhary K, Vy HMT, Petrazzini BO, Bafna S, Jordan DM, Rocheleau G, Loos RJF, Nadkarni GN, Cho JH, Do R. Forrest IS, et al. Among authors: jordan dm. JAMA. 2022 Jan 25;327(4):350-359. doi: 10.1001/jama.2021.23686. JAMA. 2022. PMID: 35076666 Free PMC article.

10

A tissue-level phenome-wide network map of colocalized genes and phenotypes in the UK Biobank.

Rocheleau G, Forrest IS, Duffy Á, Bafna S, Dobbyn A, Verbanck M, Won HH, Jordan DM, Do R. Rocheleau G, et al. Among authors: jordan dm. Commun Biol. 2022 Aug 20;5(1):849. doi: 10.1038/s42003-022-03820-z. Commun Biol. 2022. PMID: 35987940 Free PMC article.

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