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Page 1
Catabolism of extracellular glutathione supplies amino acids to support tumor growth.
Hecht F, Zocchi M, Tuttle ET, Ward NP, Smith B, Kang YP, Cazarin J, Soares ZG, Ozgurses ME, Zhao H, Sheehan C, Alimohammadi F, Munger LD, Trivedi D, Asantewaa G, Blick-Nitko SK, Zoeller JJ, Chen Y, Vasiliou V, Turner BM, Muir A, Coloff JL, Munger J, DeNicola GM, Harris IS. Hecht F, et al. Among authors: ozgurses me. bioRxiv [Preprint]. 2024 Oct 13:2024.10.10.617667. doi: 10.1101/2024.10.10.617667. bioRxiv. 2024. PMID: 39416022 Free PMC article. Preprint.
ASCT2 is a major contributor to serine uptake in cancer cells.
Conger KO, Chidley C, Ozgurses ME, Zhao H, Kim Y, Semina SE, Burns P, Rawat V, Lietuvninkas L, Sheldon R, Ben-Sahra I, Frasor J, Sorger PK, DeNicola GM, Coloff JL. Conger KO, et al. Among authors: ozgurses me. Cell Rep. 2024 Aug 27;43(8):114552. doi: 10.1016/j.celrep.2024.114552. Epub 2024 Jul 27. Cell Rep. 2024. PMID: 39068660 Free PMC article.
Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy.
Rawat V, DeLear P, Prashanth P, Ozgurses ME, Tebeje A, Burns PA, Conger KO, Solís C, Hasnain Y, Novikova A, Endress JE, González-Sánchez P, Dong W, Stephanopoulos G, DeNicola GM, Harris IS, Sept D, Mason FM, Coloff JL. Rawat V, et al. Among authors: ozgurses me. JCI Insight. 2024 May 30;9(13):e174329. doi: 10.1172/jci.insight.174329. JCI Insight. 2024. PMID: 38815134 Free PMC article.
ASCT2 is the primary serine transporter in cancer cells.
Conger KO, Chidley C, Ozgurses ME, Zhao H, Kim Y, Semina SE, Burns P, Rawat V, Sheldon R, Ben-Sahra I, Frasor J, Sorger PK, DeNicola GM, Coloff JL. Conger KO, et al. Among authors: ozgurses me. bioRxiv [Preprint]. 2023 Oct 11:2023.10.09.561530. doi: 10.1101/2023.10.09.561530. bioRxiv. 2023. PMID: 37873453 Free PMC article. Preprint.
Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy.
Rawat V, DeLear P, Prashanth P, Ozgurses ME, Tebeje A, Burns PA, Conger KO, Solís C, Hasnain Y, Novikova A, Endress JE, González-Sánchez P, Dong W, Stephanopoulos G, DeNicola GM, Harris IS, Sept D, Mason FM, Coloff JL. Rawat V, et al. Among authors: ozgurses me. bioRxiv [Preprint]. 2023 Jul 28:2023.07.26.550731. doi: 10.1101/2023.07.26.550731. bioRxiv. 2023. Update in: JCI Insight. 2024 May 30;9(13):e174329. doi: 10.1172/jci.insight.174329. PMID: 37546939 Free PMC article. Updated. Preprint.