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Plasma proteome-wide analysis of cerebral small vessel disease identifies novel biomarkers and disease pathways.
Gomez GT, Shi L, Fohner AE, Chen J, Yang Y, Fornage M, Duggan MR, Peng Z, Daya GN, Tin A, Schlosser P, Longstreth WT, Kalani R, Sharma M, Psaty BM, Nevado-Holgado AJ, Buckley NJ, Gottesman RF, Lutsey PL, Jack CR, Sullivan KJ, Mosley T, Hughes TM, Coresh J, Walker KA. Gomez GT, et al. Among authors: shi l. medRxiv [Preprint]. 2024 Oct 8:2024.10.07.24314972. doi: 10.1101/2024.10.07.24314972. medRxiv. 2024. PMID: 39417098 Free PMC article. Preprint.
Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life.
Walker KA, Chen J, Shi L, Yang Y, Fornage M, Zhou L, Schlosser P, Surapaneni A, Grams ME, Duggan MR, Peng Z, Gomez GT, Tin A, Hoogeveen RC, Sullivan KJ, Ganz P, Lindbohm JV, Kivimaki M, Nevado-Holgado AJ, Buckley N, Gottesman RF, Mosley TH, Boerwinkle E, Ballantyne CM, Coresh J. Walker KA, et al. Among authors: shi l. Sci Transl Med. 2023 Jul 19;15(705):eadf5681. doi: 10.1126/scitranslmed.adf5681. Epub 2023 Jul 19. Sci Transl Med. 2023. PMID: 37467317 Free PMC article.
Plasma Proteomic Biomarkers Relating to Alzheimer's Disease: A Meta-Analysis Based on Our Own Studies.
Shi L, Buckley NJ, Bos I, Engelborghs S, Sleegers K, Frisoni GB, Wallin A, Lléo A, Popp J, Martinez-Lage P, Legido-Quigley C, Barkhof F, Zetterberg H, Visser PJ, Bertram L, Lovestone S, Nevado-Holgado AJ. Shi L, et al. Front Aging Neurosci. 2021 Jul 21;13:712545. doi: 10.3389/fnagi.2021.712545. eCollection 2021. Front Aging Neurosci. 2021. PMID: 34366831 Free PMC article.
Identification of plasma proteins relating to brain neurodegeneration and vascular pathology in cognitively normal individuals.
Shi L, Buchanan CR, Cox SR, Hillary RF, Marioni RE, Campbell A, Hayward C, Stolicyn A, Whalley HC, Harris MA, Waymont J, Waiter G, Backhouse E, Wardlaw JM, Steele D, Mcintosh A, Lovestone S, Buckley NJ, Nevado-Holgado AJ. Shi L, et al. Alzheimers Dement (Amst). 2021 Sep 27;13(1):e12240. doi: 10.1002/dad2.12240. eCollection 2021. Alzheimers Dement (Amst). 2021. PMID: 34604499 Free PMC article.
Genome- and epigenome-wide studies of plasma protein biomarkers for Alzheimer's disease implicate TBCA and TREM2 in disease risk.
Hillary RF, Gadd DA, McCartney DL, Shi L, Campbell A, Walker RM, Ritchie CW, Deary IJ, Evans KL, Nevado-Holgado AJ, Hayward C, Porteous DJ, McIntosh AM, Lovestone S, Robinson MR, Marioni RE. Hillary RF, et al. Among authors: shi l. Alzheimers Dement (Amst). 2022 Apr 20;14(1):e12280. doi: 10.1002/dad2.12280. eCollection 2022. Alzheimers Dement (Amst). 2022. PMID: 35475137 Free PMC article.
Predicting AT(N) pathologies in Alzheimer's disease from blood-based proteomic data using neural networks.
Zhang Y, Ghose U, Buckley NJ, Engelborghs S, Sleegers K, Frisoni GB, Wallin A, Lleó A, Popp J, Martinez-Lage P, Legido-Quigley C, Barkhof F, Zetterberg H, Visser PJ, Bertram L, Lovestone S, Nevado-Holgado AJ, Shi L. Zhang Y, et al. Among authors: shi l. Front Aging Neurosci. 2022 Nov 29;14:1040001. doi: 10.3389/fnagi.2022.1040001. eCollection 2022. Front Aging Neurosci. 2022. PMID: 36523958 Free PMC article.
Paired plasma lipidomics and proteomics analysis in the conversion from mild cognitive impairment to Alzheimer's disease.
Gómez-Pascual A, Naccache T, Xu J, Hooshmand K, Wretlind A, Gabrielli M, Lombardo MT, Shi L, Buckley NJ, Tijms BM, Vos SJB, Ten Kate M, Engelborghs S, Sleegers K, Frisoni GB, Wallin A, Lleó A, Popp J, Martinez-Lage P, Streffer J, Barkhof F, Zetterberg H, Visser PJ, Lovestone S, Bertram L, Nevado-Holgado AJ, Gualerzi A, Picciolini S, Proitsi P, Verderio C, Botía JA, Legido-Quigley C. Gómez-Pascual A, et al. Among authors: shi l. Comput Biol Med. 2024 Jun;176:108588. doi: 10.1016/j.compbiomed.2024.108588. Epub 2024 May 13. Comput Biol Med. 2024. PMID: 38761503 Free article.
Multiomics profiling of human plasma and cerebrospinal fluid reveals ATN-derived networks and highlights causal links in Alzheimer's disease.
Shi L, Xu J, Green R, Wretlind A, Homann J, Buckley NJ, Tijms BM, Vos SJB, Lill CM, Kate MT, Engelborghs S, Sleegers K, Frisoni GB, Wallin A, Lleó A, Popp J, Martinez-Lage P, Streffer J, Barkhof F, Zetterberg H, Visser PJ, Lovestone S, Bertram L, Nevado-Holgado AJ, Proitsi P, Legido-Quigley C. Shi L, et al. Alzheimers Dement. 2023 Aug;19(8):3350-3364. doi: 10.1002/alz.12961. Epub 2023 Feb 15. Alzheimers Dement. 2023. PMID: 36790009
Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort.
Westwood S, Baird AL, Anand SN, Nevado-Holgado AJ, Kormilitzin A, Shi L, Hye A, Ashton NJ, Morgan AR, Bos I, Vos SJB, Baker S, Buckley NJ, Ten Kate M, Scheltens P, Teunissen CE, Vandenberghe R, Gabel S, Meersmans K, Engelborghs S, De Roeck EE, Sleegers K, Frisoni GB, Blin O, Richardson JC, Bordet R, Molinuevo JL, Rami L, Wallin A, Kettunen P, Tsolaki M, Verhey F, Lléo A, Sala I, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Johannsen P, Freund-Levi Y, Frölich L, Dobricic V, Legido-Quigley C, Bertram L, Barkhof F, Zetterberg H, Morgan BP, Streffer J, Visser PJ, Lovestone S. Westwood S, et al. Among authors: shi l. J Alzheimers Dis. 2020;74(1):213-225. doi: 10.3233/JAD-190434. J Alzheimers Dis. 2020. PMID: 31985466 Free PMC article.
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